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28 de mai. de 2024 · Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited therapeutic...
30 de mai. de 2024 · In this study, we analyzed single-cell RNA sequence data of normal epithelium (NE), primary tumor of non-metastatic CRC (NMPT), primary tumor of metastatic CRC (MPT), and liver metastases (LM) of metastatic CRC from GEO dataset and identified a metastasis-related cancer cell subset named EP1.
25 de mai. de 2024 · Metastatic site combinations by early-and average-onset in adults with metastatic colorectal cancer at diagnosis. Multivariate analysis of the relationship between early-and average-onset ...
29 de mai. de 2024 · The most common metastatic sites were liver (35%), lymph nodes (43%), peritoneum (31%), and lung (15%); 48 (58%) pts had a single metastatic site. 33 (39%) pts had a mucinous adenocarcinoma, 32 (39%) BRAF mutated, 32 (39%) RAS mutated, and 26% presented a Lynch syndrome.
29 de mai. de 2024 · PDF. Abstract. 3555. Background: Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli ( APC) gene and plays a key role in tumorigenesis in colorectal cancer (CRC).
Há 3 dias · Exosomal miRNAs play a pivotal role in the crosstalk of heterogenous metastatic subclones. This study discovered that miR-20a-3p was upregulated in colorectal adenocarcinoma (CRA), correlated with metastasis, and potentially served as a prognostic indicator for CRA. miR-20a-3p could promote the proliferation, migration and invasion of CRA cells.
29 de mai. de 2024 · Relatively little is known about the real-world (rw) utilization of tumor-informed, personalized ctDNA assays in this population. We described the uptake of ctDNA testing over time as well as how results correlate with other biomarkers and the development of specific sites of metastasis (SOM).
