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24 de abr. de 2020 · Nature Communications - Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours,...
- Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Do...
- 2020
12 de jun. de 2019 · Lymph node metastasis is regarded as an indubitable prognostic factor for predicting disease recurrence and survival in patients with colorectal cancer. Lymph node status based on examination of a resected specimen is a key element of the current staging system and is also a crucial factor to determine use of adjuvant chemotherapy ...
- Hye Jin Kim, Gyu–Seog Choi
- 2019
12 de mar. de 2021 · In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.
- Hengbo Zhou, Pin-Ji Lei, Timothy P Padera
- 10.3390/cells10030627
- 2021
- Cells. 2021 Mar; 10(3): 627.
19 de set. de 2019 · Invasion-metastasis cascade: local invasion of colorectal cancer cells into surrounding matrix (Step 1), intravasation into circulatory system (blood vessels/lymphatic vessels) (Step 2), systemic transportation (Step 3), extravasation (Step 4), colonization of distant organs (liver/peritoneum) (Step 5).
- E. Pretzsch, F. Bösch, J. Neumann, P. Ganschow, A. Bazhin, M. Guba, J. Werner, M. Angele
- 10.1155/2019/7407190
- 2019
- J Oncol. 2019; 2019: 7407190.
24 de abr. de 2020 · Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely unknown. Here, we analyze the subclonal structure of 94 tumor samples, covering the primary tumors, lymph node meta …
- Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Do...
- 2020
Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely...
Tumor-draining lymph nodes (TDLNs) are located along the lymphatic drainage pathway of primary tumors and are the primary sites at which anti-tumor lymphocytes are activated by tumor-specific antigens. 1 TDLNs contain tumor-specific T cells and are a good source of T cells for colorectal cancer (CRC) immunotherapy.
