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  1. www.nature.com › articles › s41467/020/15886-6Mapping the spreading routes of lymphatic metastases ... - Nature

    24 de abr. de 2020 · Nature Communications - Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours,...

  2. www.ncbi.nlm.nih.gov › pmc › articlesClinical Implications of Lymph Node Metastasis in Colorectal ...

    12 de jun. de 2019 · Lymph node metastasis is regarded as an indubitable prognostic factor for predicting disease recurrence and survival in patients with colorectal cancer. Lymph node status based on examination of a resected specimen is a key element of the current staging system and is also a crucial factor to determine use of adjuvant chemotherapy ...

  3. www.ncbi.nlm.nih.gov › pmc › articlesProgression of Metastasis through Lymphatic System - PMC

    12 de mar. de 2021 · In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.

  4. www.ncbi.nlm.nih.gov › pmc › articlesMechanisms of Metastasis in Colorectal Cancer and Metastatic ...

    19 de set. de 2019 · Invasion-metastasis cascade: local invasion of colorectal cancer cells into surrounding matrix (Step 1), intravasation into circulatory system (blood vessels/lymphatic vessels) (Step 2), systemic transportation (Step 3), extravasation (Step 4), colonization of distant organs (liver/peritoneum) (Step 5).

  5. pubmed.ncbi.nlm.nih.gov › 32332722Mapping the spreading routes of lymphatic metastases ... - PubMed

    24 de abr. de 2020 · Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely unknown. Here, we analyze the subclonal structure of 94 tumor samples, covering the primary tumors, lymph node meta …

  6. www.nature.com › articles › s41467/020/15886-6Mapping the spreading routes of lymphatic metastases in human ...

    Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). How tumor cells disseminate within the lymphatic network remains largely...

  7. jitc.bmj.com › content › 12Tumor-draining lymph nodes: opportunities, challenges, and ...

    Tumor-draining lymph nodes (TDLNs) are located along the lymphatic drainage pathway of primary tumors and are the primary sites at which anti-tumor lymphocytes are activated by tumor-specific antigens. 1 TDLNs contain tumor-specific T cells and are a good source of T cells for colorectal cancer (CRC) immunotherapy.