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The mission of IRIS is to help veterinary practitioners better diagnose, understand and treat kidney disease in cats and dogs. We hope you find this site useful and informative. Provides additional information on specific aspects of kidney diseases. Contains regularly updated articles written by IRIS Board members.
- Guidelines
The mission of IRIS is to help veterinary practitioners...
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IRIS was created to advance the scientific understanding of...
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- IRIS Staging of CKD
Based on these categories, some empirical recommendations...
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At its 2011 meeting in Denver, the IRIS Board approved the...
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The IRIS AKI Grading scale (I-V) for dogs and cats is based...
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A persistent increase in SDMA above 14 µg/dl suggests...
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>> Announcement concerning changes to IRIS guidelines 2023.
Chronic kidney disease (CKD) is diagnosed based on evaluation of all available clinical and diagnostic information in a stable patient. Following diagnosis of CKD, the IRIS Board recommends using serum creatinine or SDMA (ideally both) to stage CKD with substaging based on assessment of arterial blood pressure and proteinuria. Diagnosing, Staging,
- Staging Guidelines
- Treatment Recommendations For Cats
- Treatment Recommendations For Dogs
The section relating to discrepancies between creatinine and SDMA was felt to be in need of updating to include mention of breed specific reference ranges for both creatinine and SDMA and instances recognised where SDMA is elevated because of non-renal disease (e.g. lymphoma) where creatinine is not elevated. Amendments to the education article on ...
Four main changes have been introduced to the cat treatment recommendations. These are: 1. The recommendation that clopidogrel should be the first line drug recommended for cats with protein losing nephropathy considered at risk of thromboembolic disease and the removal of serum albumin (<2.0 g/dl) as a definitive trigger for such therapy. 2. The i...
The main changes introduced for the dog treatment recommendations were as follows: 1. In the management of proteinuria at all stages it was recommended that: a. Reduction of UPC below 0.5 was not possible in many patients with primary glomerular disease and that a more realistic treatment goal is a 50% reduction in UPC from pre-treatment baseline a...
IRIS Treatment Recommendations for CKD. All treatments for chronic kidney disease (CKD) need to be tailored to the individual patient. The following recommendations are useful starting points for the majority of animals at each stage.
IRIS Staging of CKD (modified (modified in 2023) 2019) Discrepancies between creatinine and SDMA . IRIS CKD staging is based on fasting blood creatinine concentration and blood SDMA concentration. SDMA may be a more sensitive marker that is less impacted by loss of lean body mass. DOGS:
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