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Atopic dermatitis falls under the spongiotic dermatosis pattern histologically; spongiotic dermatitis is a microscopic terminology while atopic dermatitis (eczema) is a clinical diagnosis Microscopically, atopic dermatitis is broken down into 3 stages
- Terminology
- Pathophysiology
- Classification
- Symptoms
- Prognosis
- Epidemiology
- Signs and symptoms
- Mechanism
- Diagnosis
- Nomenclature
Eczema is a common skin condition with multiple clinical patterns, characterised histologically by a spongiotic tissue reaction pattern. The terms eczema and dermatitis are often used interchangeably to denote a polymorphic inflammatory reaction pattern involving the epidermis and dermis. However, 'dermatitis' means inflammation of the skin and is ...
The spongiotic tissue reaction pattern is characterised by intercellular oedema within the epidermis (spongiosis). Initially, there is a widening of intercellular spaces between keratinocytes and elongation of the intercellular bridges. Further accumulation of fluid leads to the formation of intraepidermal vesicles. Spongiotic dermatitis is a dynam...
Clinically, eczema is grouped according to aetiology. Histologically, it is more useful to classify eczema based on chronicity. Histologically, there are three stages of eczema: acute, subacute, and chronic. An eczematous disease may start at any stage and evolve into another.
This is the most frequently encountered type of spongiotic dermatitis. The degree of spongiosis and exocytosis of inflammatory cells is mild to moderate. Irregular acanthosis and parakeratosis are additional features compared with acute spongiotic dermatitis. A superficial dermal perivascular lymphohistiocytic inflammatory infiltrate, swelling of e...
In chronic spongiotic dermatitis, the degree of spongiosis is often mild and difficult to appreciate. Vesiculation is uncommon. There is significant epidermal acanthosis, which may show a psoriasiform pattern with hyperkeratosis, hypergranulosis and minimal parakeratosis. Fibrosis of the papillary dermis may be present (figure 3).
Atopic dermatitis is a common skin condition, particularly in children and is associated with personal and family history of atopy. Although acute and subacute spongiotic patterns have been described in atopic dermatitis, these are far less common than chronic spongiosis. Interestingly, a follicular pattern is not uncommon which shows spongiosis of...
Discoid eczema or nummular dermatitis is a particularly chronic eczema characterised clinically by papules or papulovesicles which coalesce into coin-shaped patches. Histological changes vary with chronicity. Early lesions show moderate spongiosis with mild acanthosis and exocytosis of inflammatory cells. With time, the degree of acanthosis increas...
Id reaction or autoeczematisation describes the occurrence of generalised eczema in response to a localised dermatosis or infection at a distant site. Clinically the Id reaction is polymorphous including pompholyx-like reactions affecting hands and feet or more generalised papular eruptions. Histology of the id reaction often mimics that of the ini...
Acral skin can be easily identified histologically due to the thickness of the stratum corneum and absence of follicular structures. The acute form of vesicular hand dermatitis is characterised by intraepidermal spongiotic vesicles or bullae. The epidermal thickness is normal (figure 13). In chronic hand dermatitis, there is a predominance of parak...
More often than not, histopathologic examination does not allow for a more explicit designation of the aetiology or pathogenesis. It is incumbent on the pathologist to attempt to be as specific as possible, and on the referring physician to provide pertinent clinical information.
21 de jun. de 2018 · Nature Reviews Disease Primers - Atopic dermatitis is a chronic inflammatory skin disease with a complex pathophysiology. Although it is not a life-threatening disease, it has considerable...
- Stephan Weidinger
Pathogenesis and histopathological changes in atopic eczema are still a matter of controversy [9, 24, 26–29, 33]. Basically, an unequivocal diagnosis of atopic eczema, by histological means alone, is hampered for the following reasons: 1. The primary lesion of atopic eczema remains to be defined both clinically and histologically.
- E. Eckert
- 1991
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic predisposition, epidermal barrier disruption, and dysregulation of the immune system are some of the critical components of AD.
- Jihyun Kim, Byung Eui Kim, Donald Y. M. Leung
- 10.2500/aap.2019.40.4202
- 2019
- Allergy Asthma Proc. 2019 Mar; 40(2): 84-92.
14 de mar. de 2024 · Atopic dermatitis’ histopathology is mainly represented by spongiosis and perivascular dermal infiltration of T cells and macrophages. Atopic dermatitis has a chronic and fluctuating course that can lead to a decreased quality of life for patients, so it is important to recognize and treat AD when applicable. Keywords. Incidence. Prevalence.
24 de mar. de 2021 · Atopic dermatitis is one of the most prevalent inflammatory skin diseases. It usually develops in childhood and may persist into adulthood; less frequently, it starts in midlife or late life....
