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Alan Lloyd Hodgkin e Andrew Huxley descreveram o modelo em 1952 para explicar os mecanismos iônicos subjacentes à iniciação e propagação dos potenciais de ação no axônio gigante de lula. [1] Em 1963, eles receberam o Prêmio Nobel em Fisiologia ou Medicina por este trabalho.
Com base nos seus estudos experimentais, Hodgkin e Huxley postularam o seguinte modelo fenomenológico para explicar os eventos observados durante a ocorrência de um potencial de ação no axônio gigante da lula;
The Nobel Prize in Physiology or Medicine 1963 was awarded jointly to Sir John Carew Eccles, Alan Lloyd Hodgkin and Andrew Fielding Huxley "for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane"
10 de out. de 2012 · A series of papers published in The Journal of Physiology in 1952 revolutionized our understanding of neuronal function: Alan Hodgkin and Andrew Huxley used the experimental data from a sequence of papers on voltage-dependent conductances in the squid giant axon (Hodgkin et al., 1952; Hodgkin and Huxley, 1952a–c) to propose a model ...
- William A. Catterall, Indira M. Raman, Hugh P. C. Robinson, Terrence J. Sejnowski, Terrence J. Sejno...
- 2012
1 de jun. de 2012 · Working together in 1939, and again from 1946 to 1952, Alan Hodgkin and Andrew Huxley formed one of the most productive and influential collaborations in the history of physiology. Their work, both in the Physiological Laboratory in Cambridge and at the Laboratory of the Marine Biological Association in Plymouth, provided fundamental ...
- Christof J. Schwiening
- 10.1113/jphysiol.2012.230458
- 2012
- J Physiol. 2012 Jun 1; 590(Pt 11): 2571-2575.
Alan Hodgkin and Andrew Huxley described the model in 1952 to explain the ionic mechanisms underlying the initiation and propagation of action potentials in the squid giant axon. They received the 1963 Nobel Prize in Physiology or Medicine for this work.
3 de jan. de 2023 · 51 Citations. 10 Altmetric. Metrics. The Hodgkin-Huxley (H-H) theory of the action potential, formulated 50 years ago, remains one of the great success stories in biology, and ranks among the...
