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CD9 is commonly used as a marker for exosomes as it is contained on their surface. However, in some cases CD9 plays a larger role in the ability of exosomes to be more or less pathogenic. Shown in HIV-1 infection, exosomes are able to enhance HIV-1 entry through tetraspanin CD9 and CD81.
- CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29, CD9 molecule
2 de abr. de 2024 · GeneCards Summary for CD9 Gene. CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Diphtheria and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Uptake and actions of bacterial toxins .
28 de abr. de 2020 · CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection.
- Jung Hee Cho, Jung Hee Cho, Eok-Cheon Kim, Youlim Son, Da-Woon Lee, Yong Seop Park, Joon Hyuk Choi, ...
- 2020
30 de mar. de 2020 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.
- Rie Umeda, Yuhkoh Satouh, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi...
- 2020
9 de out. de 2018 · The role of CD9 in cancer is quite controversial. CD9 expression is sometimes correlated with better survival, and CD9 is sometimes used as a biomarker of invasion and late stages. CD9 is reported to suppress motility and to promote adherence, leading to the suppression of tumor progression.
- Carole Brosseau, Luc Colas, Antoine Magnan, Sophie Brouard
- 10.3389/fimmu.2018.02316
- 2018
- Front Immunol. 2018; 9: 2316.
18 de fev. de 2021 · • CD9: favorable prognostic marker for inhibition of cell migration• CD9 and CD26 co-modulated with each other. Depletion of CD26 led to an increase in CD9 and vice versa. CD9 depletion led to enhanced invasiveness. CD9 negatively regulated tumor cell invasion by reducing the level of CD26-α5β1 integrin complex: 143, 144 ...
CD9 is a tetramembrane-spanning protein that physically interacts with the proHB-EGF ectodomain and up-regulates the number of functional DT receptors and enhances sensitivity to DT. CD9 does not affect the expression level of proHB-EGF or the binding affinity of DT. CD9 also potentiates the juxtacrine activities of proHB-EGF.
