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AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4- prenyl - piperazine derivative, which is structurally unrelated to most other opioid drugs. The ( S )-enantiomers in this series are more active as opioid agonists, but the less active ( R )-enantiomer of this compound ...
t. e. The history of Africa begins with the emergence of hominids, archaic humans and — around 300,000–250,000 years ago — anatomically modern humans ( Homo sapiens ), in East Africa, and continues unbroken into the present as a patchwork of diverse and politically developing nation states. [1]
1159–1160. Nengō. Enkyō 4. (延享4年) Juliansk kalender. Gregoriansk minus 11 dager. Koreansk kalender. 4080. 1747 ( MDCCLXVII) i den gregorianske kalender var et år uten skuddag som begynte på en søndag .
Knowles Riot. The Knowles Riot, also known as the Impressment Riot of 1747, was a three-day riot in Boston that began on 17 November 1747, in response to the impressment of 46 Bostonians by Admiral Charles Knowles into the navy. Hundreds of mostly working-class rioters rampaged through Boston, paralyzed the provincial government, and captured ...
September 25 – 28 – Rebel general Leo Tornikios (a nephew of Emperor Constantine IX) proclaims himself emperor at Adrianople, and besieges Constantinople. Byzantine troops personally led by Constantine repel him, and re-occupy the walls. Tornikios is forced to withdraw, while his followers start to abandon him.
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Bailli de Suffren. The Fourth Anglo-Dutch War ( Dutch: Vierde Engels-Nederlandse Oorlog; 1780–1784) was a conflict between the Kingdom of Great Britain and the Dutch Republic. The war, contemporary with the War of American Independence (1775–1783), broke out over British and Dutch disagreements on the legality and conduct of Dutch trade ...
