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  1. eBowel Project Protocol C-03. J Clin Oncol 1993; 11: 1879–1887. 5. Benson AB, et al. NCCN practice guidelines for colorectal cancer. Oncology 2000;14:203–212. 6. de Gramont A, et al. Oxaliplatin/5-FU/LV in adjuvant colon cancer: results of the international randomized mosaic trial. Proc Am Soc Clin Oncol 2003;22:253 (abstract 1015).

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  2. Critérios para inclusão de esquemas de tratamento no protocolo e modificação. destes: 1) O material aqui disponibilizado é, essencialmente, uma relação de. protocolos e recomendações cientificamente reconhecidas. Não tem. como objetivo interferir na conduta médica ou autonomia profissional.

  3. Adjuvant: Folinic Acid and 5-Fluorouracil are administered once weekly for 6 weeks followed by a 2 week break (1 cycle = 8weeks) for 3 cycles or until disease progression or unacceptable toxicity develops. Facilities to treat anaphylaxis MUST be present when systemic anti-cancer therapy (SACT) is administered.

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  4. The weekly fluorouracil (5-FU) plus leucovorin regimen, also commonly referred to as the Roswell Park regimen was evaluated for its efficacy by the National Surgical Adjuvant Breast and Bowel Project (NSABP C-03 trial) in patients with Duke's B and C colorectal cancer. r

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  6. combinada à Quimioterapia para aumentar o controle pélvico. Em casos selecionados, excepcionalmente o tratamento sistêmico como modalidade única pode ser recomendado. Os protocolos de tratamento são os mesmos de Cólon (C18).

  7. At Roswell Park, a center of excellence for colorectal cancer care, you’ll have more experienced surgeons and oncologists, cutting-edge technologies, the latest treatments, and support services integrated into your personalized treatment plan, that result in a level of cancer care unrivaled in the region.