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genes do M. leprae possam ser expressos em E. coli, contribuindo de forma importante para o estudo de antígenos protéicos, e, mais recentemente, a transferência de genes entre as micobactérias permitindo que se conheça melhor alguns aspectos bioquímicos do bacilo. Com o avanço da biologia molecular; espera-se que
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A M. leprae tem a habilidade de invadir o sistema nervoso periférico (SNP) causando diversas neuropatias, sendo seu principal alvo as células de Schwann (células que constroem mielina dos axônios).
MYCOBACTERIUM LEPRAE AS A MODEL FOR NEUROPATHOGENESIS. A classic example of an intracellular bacterial pathogen that breaches the BNB and preferentially enters the glial cells of the peripheral nerves (Schwann cells) is Mycobacterium leprae.
M. leprae, an intracellular bacterium, infects the Schwann cells of the peripheral nervous system. Several types of leprosy have been described, including indeterminate, tuberculoid, borderline tuberculoid, mid-borderline, borderline lepromatous and lepromatous, and three different forms of leprosy reactions, namely type 1, 2 and 3, have been ...
- Mohammad Ridwane Mungroo, Naveed Ahmed Khan, Ruqaiyyah Siddiqui
- 2020
In terms of its structure, biogenesis, and underlying genetics, M. leprae is an obligate intracellular parasite incapable of growth in an axenic culture. Consequently, prior to the advent of the armadillo as a source of appreciable amounts, it was available only in minute quantities from human biopsies and mouse footpads.
This chapter details a classic example of neurodegeneration, that caused by Mycobacterium leprae, which primarily infects glial cells of the peripheral nervous system (Schwann cells), and how it targets and adapts intracellularly by reprogramming Schwann cells to stem cells/progenitor cells.
17 de dez. de 2019 · Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment. Cell Microbiol 16:797–815. doi: 10.1111/cmi.12279. [PMC free article] [Google Scholar]
