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A asparagina (cuja abreviatura é Asn, ou N) é um dos vinte aminoácidos mais comuns no planeta Terra. É um composto orgânico cuja fórmula química é NH2CH (NH2)COOH, possuindo uma carboxamida como grupo funcional da cadeia lateral. É codificada pelos codões AAU e AAC do código genético.
- (2S)-2-amino-3-carbamoyl-propanoic acid
- 236
- 70-47-3
- N [C@@H] (CC (N)=O)C (O)=O
RESUMO. Introdução: A L-asparaginase tem sido estudada como alternativa no tratamento da Leucemia Linfoblástica Aguda (LLA) uma vez que possui a capacidade de induzir apoptose em células leucêmicas sem causar danos às células normais. Estudos mostraram benefícios no tratamento da LLA, porém com o risco de desenvolver efeitos adversos.
A asparagina é um aminoácido não essencial importante para o desenvolvimento e saúde dos neurônios e transmissão de informações do sistema nervoso. Também colabora com o aumento da resistência física do corpo à fadiga.
Asparaginase é indicado como componente de uma terapêutica antineoplásica combinada para o tratamento da leucemia linfoblástica aguda (LLA) em doentes pediátricos desde o nascimento até aos 18 anos. Quais as contraindicações do Asparaginase?
- Introduction
- Reactions and Mechanism
- L-Asparaginase Applications
- Industrial Production of L-Asparaginase
- Conclusion and Future Recommendations
L-asparaginase aminohydrolase (L-asparaginase, EC 3.5.1.1), has gained attention in recent years due to its important applications, as its use in pharmaceutical industry as an alternative for treatment of different cancers such as acute lymphoblastic leukemia, malignant diseases of the lymphoid system and Hodgkin's lymphomas.11 Appel IM, van Kessel...
The hydrolysis process occurs in two steps through an intermediate: beta-acyl-enzyme (Fig. 1). In the first process step, the nucleophilic residue of the enzyme is activated by a strong base and attacks the amide carbon atom of L-asparagine (substrate), generating a product beta-acyl-enzyme intermediate. The second reaction step is an attack on the...
Pharmaceutical industry: antineoplastic action
The L-asparagine enzymatic hydrolysis in L-aspartate and ammonium was observed in a first time by Lang (1904),1414 Lang S. Uber desamidierung im Tierkorper. Beitr Chem Physiol Pathol. 1904;5:321-345. that detected L-asparaginase activity in bovine's tissues. Results of this researcher were confirmed by Furth and Friedmann (1910),1515 Furth O, Friedmann M. Uber die Verbreitung asparaginspaltender Organfermente. Biochemistry. 1910;26:435-440. that detected L-asparagine hydrolase in horse and pi...
Food industry: acrylamide formation
Acrylamide (C3H5NO) is also known as 2-propenamide, acrylic amide, ethylene carboxamide, propenamide, propanoic acid amide, monomer of acrylamide or acrylic acid amide, presenting 71.08 g/mol of molecular mass.2222 Friedman M. Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem. 2003;51(16):4504-4526, http://dx.doi.org/10.1021/jf030204+. http://dx.doi.org/10.1021/jf030204+... Several studies show that L-asparagine is the main amino acid responsible for acrylamide pr...
Production by different microorganisms
L-asparaginase is present in mammals, birds, plants, yeast, and a wide range of bacteria.1010 El-Bessoumy AA, Sarhan M, Mansour J. Production, isolation, and purification of L-asparaginase from Pseudomonas aeruginosa 50071 using solid-state fermentation. J Biochem Mol Biol. 2004;37(4):387-393, http://dx.doi.org/10.5483/BMBRep.2004.37.4.387. http://dx.doi.org/10.5483/BMBRep.2004.37... ,2929 Wriston JC, Yellin TO. L-asparaginase: a review. Adv Enzymol Relat Areas Mol Biol. 1973;39:185-248. http...
For industrial production of L-asparaginase, many factors need to be taken into account aiming to a process with higher yield and economic viability. For example, type and concentration of carbon and nitrogen sources, pH, aeration, temperature, fermentation time, and, mainly, the microbial agent, have great influence in the process.5252 Gurunathan ...
L-asparaginase is an interesting enzyme with important applications in pharmaceutical and food industry. However, its use in these industrial sectors requires some specific properties, as security for use by humans. As chemotherapeutic agent, an efficient action is required, in addition to reduced adverse effects, such as hypersensitivity and immun...
- Jorge Javier Muso Cachumba, Felipe Antonio Fernandes Antunes, Guilherme Fernando Dias Peres, Larissa...
- 2016
L-asparagine is an optically active form of asparagine having L-configuration. It has a role as a nutraceutical, a micronutrient, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite and a plant metabolite.
A L-asparaginase tem sido estudada como alternativa no tratamento da Leucemia Linfoblástica Aguda (LLA) uma vez que possui a capacidade de induzir apoptose em células leucêmicas sem causar danos às células normais.
