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Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene.
- COMT, HEL-S-98n, catechol-O-methyltransferase
A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas ( dopamina, epinefrina e norepinefrina ). [ 3] Referências. ↑ «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata» ↑ «Human PubMed Reference:»
Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features. The most common class of methyltransferases is class I, all of which contain a Rossmann fold for binding S -Adenosyl methionine (SAM).
Catechol- O -methyl transferase (COMT) is an enzyme that catalyzes local conversion of hydroxylated estrogen metabolites which has antiestrogenic effect to the more estrogenic methylated forms. Fibroids are known to have high levels of COMT and thus are able to promote the growth stimulating effect of estradiol.
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Although its classical function has been established for more than five decades, a …
- Pedro Bastos, Tiago Gomes, Laura Ribeiro
- 2017
O-Methylation by catechol-O-methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. A single gene encodes both membrane bound (MB) and soluble (S) forms of COMT. The COMT gene contains 34 single nucleotide polymorphisms (SNPs).
De Wikipedia, a enciclopédia encyclopedia. A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas ( dopamina, epinefrina e norepinefrina ). Factos rápidos COMT, Estruturas disponíveis ... Fechar. Referências. [1]
