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24 de abr. de 2020 · Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and...
- Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Do...
- 2020
12 de mar. de 2021 · In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.
- Hengbo Zhou, Pin-Ji Lei, Timothy P Padera
- 10.3390/cells10030627
- 2021
- Cells. 2021 Mar; 10(3): 627.
6 de jun. de 2019 · Positive lymph node status was reported to be the only significant independent predictor of 5-year cancer specific survival and 5-year disease-free survival in patients with pT1 and pT2...
- Fanny Barel, Mélanie Cariou, Philippe Saliou, Tiphaine Kermarrec, Anaïs Auffret, Laura Samaison, Amé...
- 2019
24 de dez. de 2020 · Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, analyzing signaling pathways involved in CRC metastasis is necessary to elucidate the underlying mechanism of CRC progression and pharmacotherapy.
- Ahmed Malki, Rasha Abu ElRuz, Ishita Gupta, Asma Allouch, Semir Vranic, Ala-Eddin Al Moustafa
- 2020
19 de set. de 2019 · Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The most common sites of metastasis are the liver and the peritoneum. Peritoneal carcinomatosis is often considered the end stage of the disease after the tumor has spread to the liver.
- E. Pretzsch, F. Bösch, J. Neumann, P. Ganschow, A. Bazhin, M. Guba, J. Werner, M. Angele
- 10.1155/2019/7407190
- 2019
- J Oncol. 2019; 2019: 7407190.
The invasion of lymphatic vessels by colorectal cancer (CRC) and its subsequent spread to draining lymph nodes is a key determinant of prognosis in this common and frequently fatal malignancy.
24 de jul. de 2020 · The liver is the most frequent target of metastatic spread owing to the fact that most of the intestinal mesenteric drainage enters the hepatic portal venous system [ 6 ]. Nearly half of patients undergoing surgical resection for their primary CRC will eventually develop liver metastases [ 7 ].
