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CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family.
2 de abr. de 2024 · CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Diphtheria and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Uptake and actions of bacterial toxins .
28 de abr. de 2020 · CD9 knockdown in senescent human umbilical vein endothelial cells significantly rescued senescence phenotypes, while CD9 upregulation in young cells accelerated senescence.
- Jung Hee Cho, Jung Hee Cho, Eok-Cheon Kim, Youlim Son, Da-Woon Lee, Yong Seop Park, Joon Hyuk Choi, ...
- 2020
30 de mar. de 2020 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.
- Rie Umeda, Yuhkoh Satouh, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi...
- 2020
9 de out. de 2018 · CD9 (also known as TSPAN29, Leukemia-Associated Cell Surface Antigen p24, and Motility-Related Protein-1) is a member of the tetraspanin superfamily. CD9 was first identified by Kersey et al. as the human lymphohematopoietic progenitor cell surface antigen p24 using a monoclonal antibody that bound to acute lymphoblastic leukemia cells .
- Carole Brosseau, Luc Colas, Antoine Magnan, Sophie Brouard
- 10.3389/fimmu.2018.02316
- 2018
- Front Immunol. 2018; 9: 2316.
29 de abr. de 2018 · CD9 is a tetraspanin protein that interacts with various membrane and cytoplasmic proteins in tetraspanin-enriched microdomains. It influences many cellular activities, including adhesion, in leukocytes and endothelial cells, and is involved in several physiological and pathological processes.
18 de fev. de 2021 · In the present minireview, we intend to provide a brief history of the field of CD9 involvement in oncogenesis and in the metastatic process of cancer, considering its potential value as a tumor-associated antigenic target.
