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Há 16 horas · Background Colorectal cancer (CRC) is a malignant tumor within the digestive tract with both a high incidence rate and mortality. Early detection and intervention could improve patient clinical outcomes and survival. Methods This study computationally investigates a set of prognostic tissue and cell features from diagnostic tissue slides. With the combination of clinical prognostic variables ...
Há 16 horas · LINC01606 is upregulated in colon cancer and associated with poor prognosis (Luo et al., 2022). Mechanistically, LINC01606 acts as a ceRNA to regulate the expression level of miR-423-5p, activating the Wnt/β-catenin signaling pathway and transcription factor E3 (TFE3), leading to enhanced LINC01606 expression by binding its promoter region.
Há 16 horas · Zebrafish patient-derived xenograft models (zAvatar) can be used to study cancer biology as well as to predict patient clinical outcomes and response to therapies. Here, in a cohort of 55 patients ...
Há 16 horas · Background Colorectal cancer (CRC) arises from complex interactions between host and environment, which include the gut and tissue microbiome. It is hypothesized that epigenetic regulation by gut microbiota is a fundamental interface by which commensal microbes dynamically influence intestinal biology. The aim of this study is to explore the interplay between gut and tissue microbiota and host ...
Há 16 horas · Colorectal cancer (CRC) poses a significant global health challenge with high morbidity and mortality rates. This study investigates the role of LY6G6D, a member of the LY6/uPAR superfamily, in CRC. Employing a bioinformatic approach, we analyzed LY6G6D expression across different cancer types, compared it with known oncogenes in CRC, explored the involved genomic alterations, and assessed ...
Há 16 horas · Tuft cells are more than guardian chemosensory elements of the digestive tract. They produce a variety of immunological effector molecules in response to stimulation; moreover, they are essential for defense against protozoa and nematodes. Beyond the description of their characteristics, this review aims to elucidate the potential pathogenic and therapeutic roles of colonic tuft cells in ...
Há 16 horas · Background Gastric cancer is one of the most common tumors worldwide, and most patients are deprived of treatment options when diagnosed at advanced stages. PRDM14 has carcinogenic potential in breast and non-small cell lung cancer. however, its role in gastric cancer has not been elucidated. Methods We aimed to elucidate the expression of PRDM14 using pan-cancer analysis. We monitored the ...
