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Coloncancer(CC)isthethirdleadingcauseofcancer-related death inadultpatientsintheUS.Anestimated106,180newCC cases and 52,580 deathsareexpected in2022. Althoughnew 1. 2 , treatments have 3 improved outcomes, thefiveyearrelativesurvival remains pooratonly64.7%. 2 Theoddsareworseforpatientswith.
22 de jun. de 2022 · CRC involves genetic and epigenetic modifications in colonic epithelium, leading to colon adenocarcinoma. The current review highlights the pathogenic mechanisms and multifactorial etiology of CRC, influenced by apoptosis, inflammation, and autophagy pathways.
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- Wnt pathway‐related biochemical process
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The Wnt signaling pathway is a complex network of protein interactions that functions most com-monly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the diferentiation fate of cells during development. The canonical ...
Inhibit the Wnt signaling pathway to explore the therapeutic targets of colorectal cancer.
Based on studying the Wnt pathway, master the biochemical processes related to the Wnt pathway, and analyze the relevant targets when drugs or inhibitors act on the Wnt pathway, to clarify the medication ideas of drugs or inhibitors for the treatment of diseases, especially colorectal cancer.
Wnt signaling pathways include: Wnt/β-catenin or canonical Wnt signaling pathway, planar cell polarity (Wnt-PCP) pathway and Wnt-Ca2+ signaling pathway. The Wnt signaling pathway is closely related to cancer cell proliferation, stemness, apoptosis, autophagy, metabolism, inflammation and immunization, microenvironment, resistance, ion channel, hete...
The development of drugs/phytochemicals and molecular inhibitors targeting the Wnt pathway can efectively treat colorectal cancer clinically. Keywords: Wnt pathway, Biochemical process, Drugs and inhibitors, Colorectal cancer
The Wnt signaling pathway is related to many bio-chemical processes, including cancer Cell Proliferation, stemness, apoptosis, autophagy, metabolism, inlamma-tion and immunization, microenvironment, resistance, ion channel, heterogeneity, EMT/migration/invasion/ metastasis (Fig. 3).
Andrographis Saffron Starch A kaurane diterpene isolated from sage
Tea polyphenols Anthocyanins/anthocyanidins Palmatine Crocin Dendrobium officinale Polysaccharides Baicalein Potato glycoalkaloids Biejiajian Pills Triptolide Norcantharidin
Tea Grape seed Cork Saffron Dendrobium officinale Scutellaria Potato ND Diterpene Triepoxide Cantharidin
Small peptide ND ND MicroRNA ND Toxoplasma Cell surface Ig superfamily proteins Small molecule Small molecule Small molecule MicroRNA Inhibitor
MicroRNA Small molecule JNK inhibitor Wnt signaling pathway inhibitor Cell adhesion molecule Small molecule Small molecule Inhibitor Cadherin Peptides Collagen lncRNA N-butyloxycarbonyl hexapeptide Peptides
We thank the members of Prof. Haibo Xu’s lab for excellent assistance and helpful discussion.
HZ and HBX conceived and designed the research project. HZ, TQM, ST, HY, MLL, SR, QT and HBX carried out the study. HZ, TQM and HBX wrote the manu-script. All authors have read and approved the manuscript for publication.
24 de mai. de 2023 · Details. Online-only access $25.00. Details. PDF download and online access $59.00. Details. Check out. Abstract. Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade.
4 de ago. de 2022 · Molecular characterization of colorectal cancer related peritoneal metastatic disease | Nature Communications. Article. Open access. Published: 04 August 2022. Molecular...
20 de jul. de 2023 · Innovative molecular subtypes of multiple signaling pathways in colon cancer and validation of FMOD as a prognostic-related marker. Research. Published: 20 July 2023. Volume 149 , pages 13087–13106, ( 2023 ) Cite this article. Download PDF. Zhujiang Dai, Xiang Peng, Xuewei Cui, Yuegui Guo, Jie Zhang, Xia Shen, Chen-Ying Liu & Yun Liu. 383 Accesses.
Há 4 dias · GAS1 suppresses TCF7L1-mediated increase in colorectal cancer cell migration and invasion. ( a) Representative images of the indicated Dox-treated CRC cell lines that were transfected with vector ...
