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CD9 is a cell surface glycoprotein that belongs to the tetraspanin family and interacts with lipids and other proteins. It plays a role in exosome biogenesis, platelet activation, muscle cell fusion, egg-sperm fusion, cell adhesion and migration, and cancer metastasis.
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30 de abr. de 2018 · The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4 + T cells, CD8 + T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells.
- Raquel Reyes, Beatriz Cardeñes, Yesenia Machado-Pineda, Carlos Cabañas, Carlos Cabañas
- 10.3389/fimmu.2018.00863
- 2018
- Front Immunol. 2018; 9: 863.
5 de ago. de 2024 · CD9 is a protein coding gene that encodes a tetraspanin family member involved in cell adhesion, differentiation, and metastasis. Learn about its aliases, disorders, pathways, products, and more from GeneCards, a comprehensive database of human genes.
30 de mar. de 2020 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.
- Rie Umeda, Yuhkoh Satouh, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi...
- 2020
28 de abr. de 2020 · CD9 knockdown in senescent human umbilical vein endothelial cells significantly rescued senescence phenotypes, while CD9 upregulation in young cells accelerated senescence.
9 de out. de 2018 · CD9 (also known as TSPAN29, Leukemia-Associated Cell Surface Antigen p24, and Motility-Related Protein-1) is a member of the tetraspanin superfamily. CD9 was first identified by Kersey et al. as the human lymphohematopoietic progenitor cell surface antigen p24 using a monoclonal antibody that bound to acute lymphoblastic leukemia cells .
