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8 de ago. de 2023 · Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis and is fairly common, often affecting infants and young children. Cutaneous lesions usually resolve spontaneously and most patients have an unremarkable course. Ocular JXG can occur and has an increased incidence in those 2 years of age or younger or in those with ...
- 2023/08/08
- Histology of Juvenile Xanthogranuloma
- Special Studies For Juvenile Xanthogranuloma
- Differential Diagnosis For Juvenile Xanthogranuloma
In juvenile xanthogranuloma, the lesion begins as a dense lymphohistiocytic proliferation of dermis with rare giant cells. As it evolves, the dermal tumour contains a population of foamy histiocytes and giant cells (figures 1–3). Touton giant cells are quite characteristic of juvenile xanthogranuloma (best seen in figure 3). These cells contain a r...
Immunohistochemistrycan be used. Typically the tumour is positive with CD68, alpha-1-antichymotrypsin, lysozyme, vimentin, and Factor XIIIa. Useful negative stains include S100 and CD1a.
5 de mai. de 2023 · Juvenile xanthogranuloma (JXG) is a benign, proliferative disorder belonging to the broad group of non-Langerhans cell histiocytoses and is typically a disorder of early childhood . JXG presents in the first two years of life as a solitary, reddish or yellowish skin papule or nodule ( picture 1D ), most often on the head, neck, or ...
What causes juvenile xanthogranuloma? Juvenile xanthogranuloma is a polyclonal proliferation of cholesterol-containing factor XIIIa-positive histiocytes, the cause of which is unknown. Theories include: Nonspecific response to injury or viral infection; Somatic gene mutations; Activation of extracellular signal-regulated kinase (ERK). What are ...
13 de jun. de 2014 · Juvenile xanthogranuloma (JXG) is a rare histiocytic disorder that typically affects children. The clinical presentation of this disease is characterized by single or, rarely, multiple yellow and brown skin nodules, most often found on the face and neck.
- Aneta Szczerkowska-Dobosz, Dorota Kozicka, Dorota Purzycka-Bohdan, Wojciech Biernat, Marta Stawczyk,...
- 10.5114/pdia.2014.40918
- 2014
- 2014/06
8 de ago. de 2023 · Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in …
19 de ago. de 2021 · Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytosis and oral mucosal involvement is exceedingly rare. Histiocytic disorders harbor activating mutations in MAPK pathway, including the report of BRAF V600E in JXG of extracutaneous site.
