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The Wnt signaling pathway is a complex network of protein interactions that functions most com-monly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the diferentiation fate of cells during development.
Coloncancer(CC)isthethirdleadingcauseofcancer-related death inadultpatientsintheUS.Anestimated106,180newCC cases and 52,580 deathsareexpected in2022. Althoughnew 1. 2 , treatments have 3 improved outcomes, thefiveyearrelativesurvival remains pooratonly64.7%. 2 Theoddsareworseforpatientswith.
24 de mai. de 2023 · Details. Online-only access $25.00. Details. PDF download and online access $59.00. Details. Check out. Abstract. Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade.
14 de mar. de 2024 · 1 Altmetric. Metrics. Abstract. Background. The Colorectal Cancer Subtyping Consortium established four Consensus Molecular Subtypes (CMS) in colorectal cancer: CMS1...
- Jaime Feliu
19 de jan. de 2022 · Background: Molecular characterisation of colorectal cancer (CRC) has demonstrated the regulatory role of epigenetic alterations, such as DNA methylation, in CRC tumorigenesis (1). Robust molecular profiling of CRC has the potential to provide critical diagnostic and prognostic information.
30 de jun. de 2022 · Article. Open access. Published: 30 June 2022. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of...
2 de dez. de 2022 · 2022 Dec 2;14(23):5958. doi: 10.3390/cancers14235958. Authors Stéphane Dedieu 1 2 , Olivier Bouché 3 4