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4 de mai. de 2020 · Intraretinal haemorrhage appeared red and radiated outward from the foveal centre in a pattern consistent with localisation to the HFL. This haemorrhage extended mostly into the outer nuclear and outer plexiform layers with some hyperreflective material also within the inner nuclear layer.
- Miaoling Li, Miaoling Li, Rosa Dolz-Marco, Jeffrey D. Messinger, Daniela Ferrara, K. Bailey Freund, ...
- 10.1038/s41433-020-0896-y
- 2021
- Eye (Lond). 2021 Feb; 35(2): 548-558.
Histologic features of a normal fovea comprise a central area exclusively containing cones with elongated outer segments (OS) underlying a capillary-free zone and surrounded by separation of inner retinal layers. 1 The advent of optical coherence tomography (OCT), which allows noninvasive, cross-sectional imaging of the retina, made possible the...
- Sarah Tick, Florence Rossant, Itebeddine Ghorbel, Alain Gaudric, José-Alain Sahel, Philippe Chaumet-...
- 2011
- Abstract
- A functional map of the primate foveola
- Discussion
- Implications for vision restoration
- Calculating the foveal center
- Acknowledgments
- Author Contributions
- Investigation: Lu Yin.
- Validation: Lu Yin.
The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However, uncovering the wiring of retinal circuitry responsible for this performance has been challenging due to the difficulty in recording receptive fields of foveal retinal ganglion cells (RGCs) in...
To produce a high-resolution functional wiring diagram of the foveola, we imaged RGC impulse responses following the presentation of randomized check stimuli on the scale of a few foveal cones (Fig 2). Only statistically significant impulse responses were mapped (see Methods). RGC receptive fields were classified as ‘ON-dominant’, those showing a p...
Building on methods introduced by Yin et al., [19] we have extracted precise topographic information about retinal structure coincident with in vivo recording from hundreds of retinal ganglion cells in an intact macaque. The high spatial resolution of the adaptive optics system allowed us to both image responsive retinal ganglion cells and to provi...
Our results have important implications for attempts to restore foveal vision in outer retinal degeneration by rendering the ganglion cells light sensitive with optogenetic methods. The dramatic dilation of ganglion cell position with respect to their respective fields creates the problem of potential gross perceptual distortion of the retinal imag...
The physiological foveal center was calculated as the convergent location of lines from each RGC through its receptive field for each field of view. This was computed by minimizing the absolute angular difference between pairs of vectors connecting this point with either each RF and the corresponding RGC soma Convergence of the nasal and temporal d...
We acknowledge The Genetically-Encoded Neuronal Indicator and Effector (GENIE) Project and the Janelia Research Campus of the Howard Hughes Medical Institute, specifically Vivek Jayaraman, Ph.D., Douglas S. Kim, Ph.D., Loren L. Looger, Ph.D., and Karel Svoboda, Ph.D. We thank Jennifer Strazzeri for assistance with eye injection and cSLO imaging, Wi...
Conceptualization: Lu Yin, David R. Williams, William H. Merigan. Data curation: Juliette E. McGregor, Lu Yin, Tyler Godat, William H. Merigan. Formal analysis: Juliette E. McGregor, Lu Yin, Qiang Yang, Tyler Godat, Khang T. Huynh. Funding acquisition: David R. Williams, William H. Merigan.
Methodology: Juliette E. McGregor, Lu Yin, Qiang Yang, Tyler Godat, David R. Williams, William H. Merigan. Project administration: Juliette E. McGregor, David R. Williams, William H. Merigan. Resources: Jie Zhang, David R. Williams, William H. Merigan. Software: Lu Yin, Qiang Yang, Tyler Godat, Khang T. Huynh. Supervision: David R. Williams, Willia...
Visualization: Juliette E. McGregor, Lu Yin, Tyler Godat, Khang T. Huynh, William H. Merigan. Writing – original draft: Juliette E. McGregor, Lu Yin, Qiang Yang, Tyler Godat, Khang T. Huynh, David R. Williams, William H. Merigan. Writing – review & editing: Juliette E. McGregor, Qiang Yang, Tyler Godat, Khang T. Huynh, David R. Williams, William H....
- Juliette E. McGregor, Lu Yin, Qiang Yang, Tyler Godat, Khang T. Huynh, Jie Zhang, David R. Williams,...
- 2018
Significance. The sharpness of our eyesight hinges on a tiny retinal region known as the fovea. The fovea is pivotal for primate vision and is susceptible to diseases like age-related macular degeneration. We studied the fovea in the marmoset—a primate with ancient evolutionary ties.
1 de ago. de 2011 · Foveal OCT scans were assessed for outer retinal structure, outer nuclear layer thickness, and hypoplasia. AOSLO images were graded as quantifiable if a peak cone density could be measured and/or usable if the location of peak density could be identified and the parafoveal mosaic was quantifiable.
- Sarim Mohammad, Irene Gottlob, Anil Kumar, Mervyn Thomas, Christopher Degg, Viral Sheth, Frank Anton...
- 2011
1 de jul. de 2023 · Fovea centralis, located at the center of the macula, is packed with cone photoreceptors and is responsible for central visual acuity. Isolated foveal photoreceptor disruption may occur in a variety of hereditary, degenerative, traumatic, and toxic chorioretinal diseases.
The foveola is the central floor of the fovea, approximately 0.35mm in diameter, and is the area of retina with the greatest visual acuity. It can be differentiated from the fovea histologically by an absence of ganglion cells and rods.
