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Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ...
- Cholinesterase inhibitor
Cholinesterase inhibitors (ChEIs), also known as anti-...
- Acetylcholinesterase
An endogenous inhibitor of AChE in neurons is Mir-132...
- Cholinesterase inhibitor
Cholinesterase inhibitors (also called acetylcholinesterase inhibitors) are a group of medicines that block the normal breakdown of acetylcholine. Acetylcholine is the main neurotransmitter found in the body and has functions in both the peripheral nervous system and the central nervous system.
Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds.
- Mirjana B Colović, Danijela Z Krstić, Tamara D Lazarević-Pašti, Aleksandra M Bondžić, Vesna M Vasić
- 10.2174/1570159X11311030006
- 2013
- 2013/05
A acetilcolinesterase (AChE) é a enzima responsável pela hidrólise do neurotransmissor acetilcolina (ACh) nas sinapses colinérgicas. Nestas sinapses a ACh atua transmitindo a mensagem de um neurônio a outro.
Acetylcholinesterase inhibitors (AChEIs) and the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine are widely utilized worldwide in the treatment of Alzheimer's disease and other dementias.
