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CD9 is commonly used as a marker for exosomes as it is contained on their surface. However, in some cases CD9 plays a larger role in the ability of exosomes to be more or less pathogenic. Shown in HIV-1 infection, exosomes are able to enhance HIV-1 entry through tetraspanin CD9 and CD81.
2 de abr. de 2024 · GeneCards Summary for CD9 Gene. CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include Diphtheria and Acquired Immunodeficiency Syndrome . Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Uptake and actions of bacterial toxins .
28 de abr. de 2020 · CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection.
- Jung Hee Cho, Jung Hee Cho, Eok-Cheon Kim, Youlim Son, Da-Woon Lee, Yong Seop Park, Joon Hyuk Choi, ...
- 2020
30 de mar. de 2020 · Here we report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.
- Rie Umeda, Yuhkoh Satouh, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi...
- 2020
29 de abr. de 2018 · CD9 is a tetraspanin protein that interacts with various membrane and cytoplasmic proteins in tetraspanin-enriched microdomains. It influences many cellular activities, including adhesion, in leukocytes and endothelial cells, and is involved in several physiological and pathological processes.
9 de out. de 2018 · The role of CD9 in cancer is quite controversial. CD9 expression is sometimes correlated with better survival, and CD9 is sometimes used as a biomarker of invasion and late stages. CD9 is reported to suppress motility and to promote adherence, leading to the suppression of tumor progression.
7 de set. de 2021 · This suggests that CD9 expression is a valuable survival factor in cancer patients. Additionally, our results revealed that increased CD9 expression was associated with increased OS in breast cancer and digestive system cancer and with increased DFS in head and neck cancer and leukemia/lymphoma.
