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Há 3 dias · Read current and featured research from the Journal of Medicinal Chemistry on ACS Publications, a trusted source for peer-reviewed journals.
Há 3 dias · Considering the promising effects of molecular hybridization on drug discovery in recent years and the ongoing endeavors to develop bioactive scaffolds tethering the 1,2,3-triazole core, the present study sought to investigate whether the 1,2,3-triazole-linked chromene and benzene sulfonamide nucleus could exhibit
Há 1 dia · Abstract. The N-benzyl piperidine (N-BP) structural motif is commonly employed in drug discovery due to its structural flexibility and three-dimensional nature. Medicinal chemists frequently utilize the N-BP motif as a versatile tool to fine-tune both efficacy and physicochemical properties in drug development.
Há 4 dias · Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC are included in dietary supplements.
Há 5 dias · Phytotherapy Research is a medicinal chemistry journal for biochemists, pharmacologists, & toxicologists interested in medicinal plant research & clinical applications.
Há 3 dias · For more information on synthetic and medicinal chemistry at BioAscent, get in touch to speak to a member of the team. References: Org. Lett. 2024, 26, 11, 2276–2281. Org. Lett. 2024, 26, 2, 456–460. Org. Lett. 2023, 25, 27, 5168–5172. About the authors: Steven Bennett is a Scientist in the Chemistry department at BioAscent.
Há 5 dias · While traditional medicinal chemistry methods have been used to develop CPPs, machine learning techniques can speed up and reduce costs in the search for new peptides. A predictive algorithm based on machine learning models was created to identify novel CPP sequences using molecular descriptors using a combination of algorithms like k-nearest neighbors, gradient boosting, and random forest.
