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Há 2 dias · For immunohistochemistry experiment, colorectal samples from 93 CRC patients without metastasis and 119 CRC patients with metastasis listed in Tables S1D and S1E were divided into paratumor regions, tumor margin regions, and cancer centers. And colorectal tumor and lung metastasis from another 9 colorectal cancer patients listed in Table S1B ...
Há 2 dias · Importantly, we characterized a brain/gut microbiota/metabolite/immune cell axis controlling cancer metastasis. Our study links the central clock in the central nervous system with MDSCs in the tumor environment, through gut microbiota and its derived metabolites, in controlling metastatic spread of CRC, uncovering an intrinsic mechanism for cancer metastasis.
Há 2 dias · Here, in patients with colorectal cancer (CRC), disturbances of circadian rhythm and the accumulation of monocytes and granulocytes were closely related to metastasis. Moreover, dysregulation of circadian rhythm promoted lung metastasis of CRC by inducing the accumulation of myeloid-derived suppressor cells (MDSCs) and dysfunctional CD8 + T cells in the lungs of mice.
Há 3 dias · Brain metastasis is a common occurrence in various cancers and affects ~16–20% of lung cancer (LC) patients during the course of their disease 1,2,3,4. Concerningly, ~30% of LC patients succumb ...
Há 5 dias · The current lack of a comprehensive understanding of brain metastasis mechanisms presents a significant gap in cancer research. This review outlines the role that Schwann cells (SCs) have in this process. SCs are already known for their role in myelination and nerve repair within the peripheral nervous system (PNS), but there is less information on their function in facilitating the transport ...
Há 3 dias · Cancer cells exhibit heterogenous metastatic potential, and high metastatic subclones can enhance metastatic potential of low metastatic subclones by transmitting some factors. Exosomal miRNAs play a pivotal role in the crosstalk of heterogenous metastatic subclones.
Há 5 dias · Izdebska et al. treated the colorectal cancer cell line LoVo with fluorouracil and found that LMNB1 overexpression inhibited the invasion and migration of colon cancer cells by inducing mitosis ...
