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Há 1 dia · A randomized study evaluating tailoring of advanced/metastatic colorectal cancer (mCRC) therapy using circulating tumor DNA (ctDNA): TACT-D. Authors : Kanwal Pratap Singh Raghav , Lianchun Xiao , Courtney Lewis , Brittany E Zeller , Michael J. Overman , Ryan W Huey , Arvind Dasari , …
Há 3 dias · Objectives Lymph node metastasis (LNM) in colorectal cancer (CRC) patients is not only associated with the tumor’s local pathological characteristics but also with systemic factors. This study aims to assess the feasibility of using body composition and pathological features to predict LNM in early stage colorectal cancer (eCRC) patients. Methods A total of 192 patients with T1 CRC who ...
Há 3 dias · Exosomal miRNAs play a pivotal role in the crosstalk of heterogenous metastatic subclones. This study discovered that miR-20a-3p was upregulated in colorectal adenocarcinoma (CRA), correlated with metastasis, and potentially served as a prognostic indicator for CRA. miR-20a-3p could promote the proliferation, migration and invasion of CRA cells.
Há 5 dias · Colorectal cancer (CRC), a pervasive and lethal malignancy of gastrointestinal cancer, imposes significant challenges due to the occurrence of distant metastasis in advanced stages. Understanding the intricate regulatory mechanisms driving CRC distant metastasis is of paramount importance.
Há 2 dias · 6. Hashiguchi Y, Muro K, Saito Y, et al: Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol 25:1-42, 2020 7. Prager GW, Taieb J, Fakih M, et al: Trifluridine-tipiracil and bevacizumab in refractory metastatic colorectal cancer. N Engl J Med 388:1657-1667, 2023 8.
Há 1 dia · Mismatch repair–deficient (dMMR) tumors can be found in 10 to 15% of patients with nonmetastatic colon cancer. In these patients, the efficacy of chemotherapy is limited. The use of neoadjuvant ...
Há 2 dias · To investigate the necessity of DKK2 in the formation of LYZ+ cancer cells during colon cancer metastasis, we employed the murine in vivo model of liver metastasis shown in Figure 1. In order to analyze transcriptome changes by Dkk2 knockout in each cell type of metastasized tumors, we performed single-cell RNA sequencing (scRNA-seq) analysis on liver metastasized AKP and KO tumor cells.
