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Há 3 dias · Atopic dermatitis (AD), a complex and heterogeneous chronic inflammatory skin disorder, manifests in a spectrum of clinical subtypes. The application of genomics has elucidated the role of genetic variations in predisposing individuals to AD. Transcriptomics, analyzing gene expression alterations, sheds light on the molecular underpinnings of AD.
Há 2 dias · Atopic dermatitis (AD) is a heterogeneous inflammatory condition involving multiple immune pathways mediated by pathogenic T cells. OX40 Ligand (OX40L) and OX40 are co-stimulatory immune checkpoint molecules that regulate effector and memory T cell activity and promote sustained immune responses in multiple immunological pathways, including Th2, Th1, Th17 and Th22.
Há 4 dias · Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, with an increasing number of targeted therapies available. While biologics to treat AD exclusively target the key cytokines of type 2 immunity, Janus kinase inhibitors target a broad variety of cytokines, including IFN-γ. To better stratify patients for optimal treatment outcomes, the identification and ...
Há 4 dias · Histopathology can be rendered useless without good clinical information, according to Dr. Olayemi Sokumbi, a dermatologist and dermatopathologist with Mayo Clinic. Next Steps in Derm, in partnership with ODAC Dermatology, Aesthetic & Surgical Conference, interviewed Dr. Sokumbi about traps to avoid in challenging clinicopathologic scenarios.
Há 5 dias · At the 2024 Fall Clinical Dermatology Conference for PAs and NPs, James Song, MD, director of clinical research at Frontier Dermatology Partners in Seattle, Washington presented a comprehensive session on deciphering therapy options for atopic dermatitis (AD).
Há 3 dias · miR-939 amplifies the S. aureus-induced atopic dermatitis phenotype in vivo We further explored the physiological relevance of miR-939 in human keratinocytes and AD mice. We mixed either the miR-939 agomir or the control agomir with in vivo -jetPEI transfection reagent and administered it through intradermal injection into the mice’s skin followed by topical application of S. aureus ( Figure ...
Há 5 dias · Burden of atopic dermatitis (AD) on quality of life. Clinical data on new and emerging therapies for AD, such as safety and efficacy profiles. Have greater competence related to. Incorporating new clinical data on AD into clinical practice. Disclosures.
