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Há 1 dia · According to the 2020 global cancer statistics released by the International Agency for Research on Cancer (IARC), CRC ranks third in the global cancer incidence rate (10.0%) and second in mortality (9.4%), 1 with colon adenocarcinoma (COAD) being one of the most common diseases. 2 COAD originates from the glandular epithelial cells of the colon and usually undergoes a process from benign ...
Há 1 dia · In general, CT has a high sensitivity and a lower specificity for detection of tumor invasion beyond the bowel wall (T1–T2 vs. T3–T4) [20, 23, 24].A meta-analysis showed suboptimal results in the detection of locally advanced colon cancer, defined by the authors as tumor invasion beyond the bowel wall of 5 mm or more (tumor stages T3c/d and T4), which remains a challenge [].
Há 3 dias · The Wnt signaling pathway is one of the most ancient and pivotal signaling cascades, governing diverse processes in development and cancer regulation. Within the realm of cancer treatment, genistein emerges as a promising candidate due to its multifaceted modulation of various signaling pathways, including the Wnt pathway. Despite promising preclinical studies, the precise mechanisms ...
Há 5 dias · Colorectal cancer, also known as bowel cancer, is a cancer formed by uncontrolled cell growth in the colon or rectum (parts of the large intestine), or in the appendix. Genetic analysis shows...
Há 5 dias · Microsatellite status should be assessed in all upper and lower gastrointestinal (GI) cancers. If an upper GI cancer is microsatellite instable (MSI), clinicians should consider treatment with an immune checkpoint inhibitor (ICI) or a combination of ICIs instead of chemotherapy. Immunotherapy is also active in lower GI cancers, where treatment is driven by microsatellite status. For upper GI ...
Há 1 dia · We further validated the expression levels of MRC1 in lung, breast, and colorectal cancer cell lines by qRT-PCR. The results showed that MRC1 expression was significantly lower in colorectal cancer cell lines (HCT116, SW480) than in normal colon epithelial cell line (FHC) (Figure 10A).
Há 2 dias · Abstract. Over the past decade, our understanding of the diversity of colorectal cancer has expanded significantly, raising hopes of tailoring treatments more precisely for individual patients. A key achievement in this direction was the establishment of the consensus molecular classification, particularly identifying the challenging consensus molecular subtype (CMS) CMS4 associated with poor ...
