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Há 4 dias · Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited therapeutic options ...
Há 2 dias · Colorectal cancer (CRC) ranks third in incidence and second in mortality among cancer globally . The main cause of death in CRC patients is metastasis, with the liver being the most frequently metastatic site. Approximately 20% of CRC patients are diagnosed with metastatic CRC and show a poor prognosis with 5-year survival lower than 20% .
Há 3 dias · 3555 Background: Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a key role in tumorigenesis in colorectal cancer (CRC). Tankyrase inhibitors, which cause degradation of β-catenin, are expected to have a promising therapeutic effect for CRC, and the short-form APC mutations predict the sensitivity of CRC cells to ...
Há 3 dias · 3610 Background: There is a growing body of evidence to support the prognostic and predictive relevance of ctDNA in patients (pts) with early stage colorectal cancer (CRC). Relatively little is known about the real-world (rw) utilization of tumor-informed, personalized ctDNA assays in this population. We described the uptake of ctDNA testing over time as well as how results correlate with ...
Há 3 dias · Abstract. Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ in features and outcomes because of variations in embryology, epidemiology, pathology, and prognosis. This...
Há 4 dias · This Review addresses the emerging focus on metastatic CRC (mCRC), which has historically been under-studied compared with primary CRC, and explores how the tumour microenvironment influences metastatic disease. Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited ...
Há 5 dias · Preoperative prediction of lymph node metastasis in colorectal cancer using 18F‐FDG PET/CT peritumoral radiomics analysis - Wang - Medical Physics - Wiley Online Library. Medical Physics. RESEARCH ARTICLE. Preoperative prediction of lymph node metastasis in colorectal cancer using 18 F-FDG PET/CT peritumoral radiomics analysis.
