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  1. Among people diagnosed with metastatic colorectal cancer, approximately 70% to 75% of patients survive beyond 1 year, 30% to 35% beyond 3 years, and fewer than 20% beyond 5 years from diagnosis. The primary treatment for unresectable metastatic CRC is systemic therapy (cytotoxic chemotherapy, biologic therapy such as antibodies to cellular ...

  2. This ESMO Clinical Practice Guideline provides key recommendations for managing metastatic colorectal cancer. It covers clinical and pathological diagnosis, staging and risk assessment, treatment and follow-up. Treatment algorithms for locoregional, advanced/metastatic and recurrent advanced colorectal cancer are provided. All recommendations ...

  3. 17 de nov. de 2023 · The incidence of bone metastasis (BM) in colorectal cancer (CRC) patients is low and the prognosis is poor. There is no clear conclusion on the risk factors affecting the survival of CRC patients with BM. The aim of this study was to investigate the factors that may affect the prognosis of CRC patients with BM. The clinical and pathological data of CRC patients with BM were retrospectively ...

  4. 20 de ago. de 2021 · Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 matched samples by using single ...

  5. 12 de mar. de 2020 · Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research ...

  6. Cáncer colorrectal metastásico. Tratamiento con un nuevo agente biológico. El cáncer colorrectal es la tercera causa de muerte por efectos de tumores cancerígenos en España, después del de pulmón en el hombre y el de mama en la mujer. Sin embargo, la identificación del receptor epidérmico humano (EGFR) y su participación en el ...

  7. 19 de set. de 2019 · Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The most common sites of metastasis are the liver and the peritoneum. Peritoneal carcinomatosis is often considered the end stage of the disease after the tumor has spread to the liver. However, almost half of CRC patients with peritoneal carcinomatosis do not present with liver metastasis. This brings up the ...