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16 de fev. de 2021 · Among people diagnosed with metastatic colorectal cancer, approximately 70% to 75% of patients survive beyond 1 year, 30% to 35% beyond 3 years, and fewer than 20% beyond 5 years from diagnosis. The primary treatment for unresectable metastatic CRC is systemic therapy (cytotoxic chemotherapy, biologic therapy such as antibodies to cellular ...
This narrative review summarizes treatment options for patients with unresectable metastatic colorectal cancer, focusing on the importance of genomic profiling to identify KRAS/NRAS/BRAF variants to guide immunotherapy.
4 de mar. de 2022 · Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death.
9 de set. de 2023 · This review focuses on metabolic reprogramming, tumor-derived exosomes, the immune system, and cancer cell-organ interactions to outline the molecular mechanisms of CRC organotropic metastasis and considers the prospect of targeting metastatic organotropism for CRC therapy. Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism ...
30 de mar. de 2022 · Metastatic colorectal cancer is an advanced condition where cancer spreads, or metastasizes, to other parts of the body. The most common organ that it spreads to is the liver. Learn more.
12 de mar. de 2020 · The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process.
15 de jul. de 2016 · In colorectal cancer patients with solitary metastases the survival differed between 5 and 19 months depending on T or N stage. Metastatic patterns differ notably between colon and rectal cancers.
