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About colorectal cancer. Colorectal cancer begins when healthy cells in the lining of the colon or rectum change and grow out of control, forming a mass called a tumor. A tumor can be cancerous or benign. A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. A benign tumor means the tumor can grow but will ...
11 de jul. de 2023 · Colorectal cancer is a type of cancer that affects the colon (large intestine) or rectum. It is one of the most common types of cancer worldwide. It can cause severe harm and death. The risk of colorectal cancer increases with age. Most cases affect people over 50 years old.
1 de mar. de 2024 · Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients.
The initial step in the formation of cancer metastasis entails the local dissemination of cancer cells derived from the primary tumor, which is instigated by modulating the TME.9 Tumor cells enhance their invasive and migratory capabilities by secreting diverse exosomes, thereby
22 de fev. de 2023 · Colorectal cancer (CRC) with deficient DNA mismatch repair (dMMR) or high microsatellite instability (MSI-H) is characterized by high tumor mutation burden that typically trigger an antitumor immune response in the tumor microenvironment. 1,2,3,4 Approximately 15% of CRC cases have dMMR, which is more commonly of sporadic origin due to methylation of the MLH1 gene promoter or is hereditary due ...
SUMMARY. Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treat-ment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival.
9 de nov. de 2022 · Metrics. Around 30–40% of patients with colorectal cancer (CRC) undergoing curative resection of the primary tumour will develop metastases in the subsequent years 1. Therapies to prevent ...
