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21 de fev. de 2021 · Colorectal cancer (CRC) is the third most common malignancy worldwide. Most patients with metastatic CRC develop liver or lung metastases, while a minority suffer from brain metastases. There is little information available regarding the presentation, treatment, and overall survival of brain metastases (BM) from CRC. This systematic review and meta-analysis includes data collected from three ...
4 de fev. de 2020 · Brain metastasis (BM) from colorectal cancer is uncommon (0.6-1.36%). This study aims to investigate the patient characteristics, treatment modalities and prognostic factors in this rare population. Methods: 104 patients with brain metastasis disease from CRC were identified from over 30,000 colorectal cancer patients at the Mayo Clinic ...
27 de mar. de 2023 · Micro-AbstractThe colorectal brain metastases (CBM) are rare, ominous and related to a dismal prognosis. There was still no standard systemic treatment for multiple or unresectable CBM. Due to highly systemic disease control rate by anti-VEGF therapy observed in patients with brain metastases from different cancers, our study was aimed to explore the impact of anti -VEGF therapy on overall ...
9 de dez. de 2014 · BACKGROUND. RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain.
1 de out. de 2019 · CRC with BM is an aggressive disease resistant to standard treatment and is associated with poor outcomes, so adding antiangiogenic therapy might be of value for patients with BM developing early in the disease course and who respond better to treatment. Introduction: Brain metastases (BM) are rare in colorectal cancer (CRC) and are associated with a dismal prognosis. This work aims to report ...
18 de jul. de 2019 · Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing (WES) and whole ...
The incidence of brain metastases from CRC is low. Primary tumor in the left colon, long-standing pulmonary metastases, especially those with recent progression, and CXCR4 expression by tumor cells are all associated with increased risk of brain metastases. Increased survival among patients with met …
