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22 de fev. de 2023 · Colorectal cancer (CRC) with deficient DNA mismatch repair (dMMR) or high microsatellite instability (MSI-H) is characterized by high tumor mutation burden that typically trigger an antitumor immune response in the tumor microenvironment. 1,2,3,4 Approximately 15% of CRC cases have dMMR, which is more commonly of sporadic origin due to methylation of the MLH1 gene promoter or is hereditary due ...
22 de mai. de 2024 · Epidemiology. Colorectal cancer is common, accounting for 15% of all newly diagnosed cancers, and tends to be a disease of the elderly, with the median age of diagnosis between 60 and 80 years of age 2, slightly younger for rectal cancer. There is also a slight male predilection for rectal cancers, not found in tumors elsewhere in the colon.
12 de jun. de 2019 · Paraaortic lymph node (PALN) metastasis is uncommon in colorectal cancer with a reported incidence rate of less than 2% but is categorized as M1 in the TNM staging system with poor survival outcomes [13, 62, 63]. However, the Japanese classification of colorectal carcinoma considers it a regional, stage III disease .
9 de nov. de 2022 · Metrics. Around 30–40% of patients with colorectal cancer (CRC) undergoing curative resection of the primary tumour will develop metastases in the subsequent years 1. Therapies to prevent ...
7 de fev. de 2023 · This short review illustrates the benefits of a multidisciplinary team approach, especially when it comes to the treatment of patients with colorectal cancer liver metastasis. Therefore, the classification to resectable and primarily unresectable disease has to be determined prior to the first treatment decision. Particularly the use of conversion chemotherapy has the potential of altering ...
11 de jul. de 2023 · Colorectal cancer is a type of cancer that affects the colon (large intestine) or rectum. It is one of the most common types of cancer worldwide. It can cause severe harm and death. The risk of colorectal cancer increases with age. Most cases affect people over 50 years old.
20 de ago. de 2021 · The immune evolution of metastasis is described and the black box of how tumors respond to neoadjuvant chemotherapy is uncovered, and scMetabolism, a computational pipeline for quantifying single-cell metabolism, is developed. Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 ...
