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To better understand metastatic colorectal cancer, the natural lymphatic drainage from the primary tumor must be examined (see Chapter 1, Fig. 1-8). Colorectal cancer arises from the mucosa and spreads radially toward the serosa. Tumor depth (or T staging) is an important predictor of lymph node involvement.
Metastasis is the leading reason for the resultant mortality of patients with cancer. The past few decades have witnessed remarkable progress in understanding the molecular and cellular basis of this lethal process in cancer. The current article summarizes some of the key progress in this area and discusses the role of cell junctions, cell adhesions, epithelial-mesenchymal transition, angio ...
29 de ago. de 2014 · The liver is the most common site of distant metastases in patients with colorectal cancer. Surgery represents the mainstream for curative treatment of colorectal cancer liver metastases (CRCLM) with long-term survival up to 58 and 36 % at 5 and 10 years, respectively. Despite advances on diagnosis, staging and surgical strategies, 60–70 % of patients will develop recurrence of the disease ...
8 de nov. de 2022 · Metastasis is the leading cause of death in colorectal cancer (CRC) patients, and the liver is the most common site of metastasis. Tumor cell metastasis can be thought of as an invasion-metastasis cascade and metastatic organotropism is thought to be a process that relies on the intrinsic properties of tumor cells and their interactions with molecules and cells in the microenvironment. Many ...
The liver is the most common site of distant metastases in patients with colorectal cancer. Surgery represents the mainstream for curative treatment of colorectal cancer liver metastases (CRCLM) with long-term survival up to 58 and 36 % at 5 and 10 years, respectively. Despite advances on diagnosis, …
4 de mar. de 2022 · Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death.
Lymphatic Metastasis. Cancer can use the lymphatic system as well as the circulatory system to metastasize. The movement of cancer cells via the lymphatic system into lymph nodes is used in the detection of metastatic disease and tumor staging. Some cancers may spread through direct contact with other organs, as in the gut cavity.
