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Há 23 horas · Colorectal cancer (CRC) is a global health concern, and the incidence of early onset (EO) CRC, has an upward trend. This study delves into the genomic landscape of EO-CRC, specifically focusing on ...
22 de jun. de 2022 · CRC involves genetic and epigenetic modifications in colonic epithelium, leading to colon adenocarcinoma. The current review highlights the pathogenic mechanisms and multifactorial etiology of CRC, influenced by apoptosis, inflammation, and autophagy pathways.
changes in guidelines recommend beginning screening for colon cancer at the age of 45. Circulating tumor DNA presents an opportunity to select patients for administration of adjuvant chemotherapy.
24 de mai. de 2023 · The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies.
19 de abr. de 2022 · Background: Colorectal cancer (CRC) is one of the most prevalent malignances worldwide. However, CRC with situs inversus totalis (SCRC) is extremely rare, and molecular characterization of this disease has never been investigated.
2 de dez. de 2022 · Colorectal cancer (CRC) is the third most diagnosed cancer worldwide, and the second leading cause of death in patients with cancer [...]. Cancers (Basel) . 2022 Dec 2;14(23):5958. doi: 10.3390/cancers14235958.
10 de nov. de 2022 · We investigated the molecular features of 133 colorectal cancer cases by comprehensive genomic profiling of 425 cancer-related genes. Consistent with previous research , APC (77.4%), TP53 (72.9%), and KRAS (53.4%) represented the most frequently mutated genes in our cohort.
