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1. link.springer.com › article › 10MIIP downregulates PD-L1 expression through HDAC6 in ...

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   Há 1 hora · Purpose Immune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many melanoma patients suffering from disease progression due to primary or secondary immune checkpoint inhibitor resistance, as is observed in the failure of anti-PD1/PD-L1 therapy. While the expression of valuable markers, such as TMB, MSI, and PD-L1 ...