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9 de jul. de 2021 · We recently introduced the Quality Control Analysis in Real Time (QC-ART) software, a tool for evaluating data as they are acquired to dynamically flag potential issues with instrument...
- Ernesto S. Nakayasu, Marina Gritsenko, Paul D. Piehowski, Yuqian Gao, Daniel J. Orton, Athena A. Sch...
- 2021
Furthermore, we describe how specialized quality control samples of varying sample complexity can be incorporated into the experimental workflow and how they can be used to rigorously assess detailed aspects of the instrument performance.
- Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Lauk...
- 2018
7 de set. de 2017 · We review potential sources of variability that can impact the results of a mass spectrometry experiment occurring in all of these steps, and we discuss how to monitor and remedy the negative influences on the experimental results.
- Wout Bittremieux, David L. Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Lauk...
- 70
- 2018
- 07 September 2017
8 de jul. de 2021 · A pooled quality-control sample allows for evaluation (and correction) of run order and batch effects within a study, but not necessarily across experiments, as is possible with reference...
- Saleh Alseekh, Asaph Aharoni, Yariv Brotman, Kevin Contrepois, John D'Auria, Jan Ewald, Jennifer C. ...
- 2021
Mass spectrometry (MS) is a powerful technique for protein identification, quantification and characterization that is widely applied in biochemical studies, and which can provide data on the quantity, structural integrity and post-translational modifications of proteins.
Isotopically-labelled internal standards are applied to assess system stability for each sample analysed. Pooled QC samples are applied to condition the analytical platform, perform intra-study reproducibility measurements (QC) and to correct mathematically for systematic errors.
8 de dez. de 2022 · Tandem mass spectrometry is increasingly utilized for clinical applications in laboratory medicine. In this Primer, Thomas et al. discuss experimental considerations and quality management...
