Resultado da Busca
In the present review, we summarize the approaches to selecting the most suitable lipid (s)-based drug delivery system, including characterization, especially for oral delivery, of both physicochemical and biopharmaceutical aspects and properties of assorted excipients as well as the related patent reports.
- Vikas Pandey, Seema Kohli
- 2018
1 de mai. de 2018 · In the present review, we summarize the approaches to selecting the most suitable lipid (s)-based drug delivery system, including characterization, especially for oral delivery, of both...
13 de jul. de 2021 · Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to...
In the present review, we summarize the approaches to selecting the most suitable lipid(s)-based drug delivery system, including characterization, especially for oral delivery, of both physicochemical and biopharmaceutical aspects and properties of assorted excipients as well as the related patent reports.
- Microemulsions
- Nanoemulsions
- Self-Emulsifying Delivery Systems
- Liposomes
- Lipid Nanoparticles
- Liposphere
- Solid Lipid Microparticle
- Nanostructured Lipid Carriers
- Niosomes
- Pharmacosomes
Microemulsions are a unique category of "dispersion" that can seem transparent or translucent. In their experimental research on the titration of long-chain fatty acids (soapy milky emulsions) with medium-/short-chain alcohols creating a translucent or transparent system of emulsions. The definition of the microemulsion is "A system of water, oil, ...
There are several approaches among them nanoemulsions for oral administration proposed as an excellent option since these possibly will improve the solubility of lipophilic medicament eventually its bioavailability increases and currently for the Class 2 & 4 (BCS) category it is highly preferred. The nanoemulsion for the oral route utilized food-gr...
As the name of SEDDS recommends that it is a binary system they can emulsify as it is composed of surfactant & oil phase, as the hydrophobic nature of active ingredients is easily solubilised in the oil phase. As the mixture of oils & surfactants with some co-solvents is added in the aqueous phase they become emulsified under delicate agitation and...
They are essentially comprised of a hydrophilic head & hydrophobic tail of hydrated phospholipids of natural as well as synthetic origin. It is prepared as spherical, concentric bilayered vesicles, in this, the aqueous phase is enveloped via bilayers of lipid. Because of the unique formation of this complex structure, the aqueous internal region of...
These types of the nanoparticulate system show fascinating highlights concerning remedial motive. The principal attribute of this system is the utilization of physiological lipids which ultimately promote the drug release in a controlled manner and improve inconsistent absorption profile in GI absorption. Furthermore, the bioavailability is improve...
Nanoparticles, microparticles, microemulsions, and liposomes are examples of multiple-unit drug delivery systems that have an advantage over single-unit systems due to their uniform distribution in the gastrointestinal tract and uniform absorption of the medication. The delivery system of these particle systems has toxicity issues due to the presen...
The solid lipid microparticles, an embedded layer of surfactant stabilizes the hydrophobic core of lipid microparticles, which are solid at body and room temperature. In the stable lipid matrix, the active substance is dissolved or disseminated . solid lipid microparticles are created by substituting a solid (at room temperature) lipid component fo...
The nanostructured lipid carriers (NLCs) Drug delivery systems contain solid and liquid lipids as a primary structural components. It was proved that NLCs offer significant benefits for medication therapy over conventional carriers, including enhanced permeability, improved bioavailability, fewer side effects, prolonged half-life, and tissue-target...
A non-ionic, surfactant-based vesicle is called a niosome. Cholesterol is included as an excipient and non-ionic surfactant forms the majority of niosomes Because they both have a bilayer; they are structurally comparable to liposomes. Niosomes are more stable due to the ingredients utilised in their preparation, nevertheless. Both lipophilic and ...
Vaizoglu and Speiser published the first review of pharmacosomes as novel drug delivery devices in 1986 . It may be possible to improve solubility and penetration while reducing gastrointestinal (GI) toxicity by developing the medications as lipid complexes, also known as pharmacosomes. With or without a spacer chain, any medication with an active ...
Key Points. Highly potent but poorly water-soluble drug (PWSD) candidates are common outcomes of contemporary drug discovery programmes. These lipophilic compounds often exhibit poor systemic...
20 de jul. de 2010 · Lipid- and surfactant-based drug delivery systems, especially SMEDDS, are a promising approach for improving the bioavailability of poorly soluble drug compounds.
![Lipid-based drug delivery systems [204,206]. | Download Scientific Diagram](https://br.images.search.yahoo.com/search/images?p=lipids+and+surfactants%3A+the+inside+story+of+lipid-based+drug+delivery+systems&nojs=1&ei=UTF-8&fl=0&rd=r2&age=1m&nocache=1&th=109&tw=114.8&imgurl=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F361535183%2Ffigure%2Ffig4%2FAS%3A1179003754942501%401658107808882%2FLipid-based-drug-delivery-systems-204-206.png&rurl=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FLipid-based-drug-delivery-systems-204-206_fig4_361535183&size=226KB&name=Lipid-based+drug+delivery+systems+%5B204%2C206%5D.+%7C+Download+Scientific+Diagram&oid=1&h=699&w=736&turl=https%3A%2F%2Ftse1.mm.bing.net%2Fth%3Fid%3DOIP.csDcBbw7mG_-cD3WHwrt2AHaHC%26pid%3DApi%26rs%3D1%26c%3D1%26qlt%3D95%26w%3D114%26h%3D109&tt=Lipid-based+drug+delivery+systems+%5B204%2C206%5D.+%7C+Download+Scientific+Diagram&sigr=Ta4lH4w5RFQX&sigit=WBbf1HTF53rq&sigi=5ll8RH_tfsuN&sign=ivFTi6uLP3c9&sigt=ivFTi6uLP3c9 "Lipid-based drug delivery systems [204,206]. | Download Scientific Diagram")
