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Clustal Omega is a new multiple sequence alignment program that uses seeded guide trees and HMM profile-profile techniques to generate alignments between three or more sequences. For the alignment of two sequences please instead use our pairwise sequence alignment tools.
CLUSTALW is a web-based tool for aligning protein or DNA sequences. You can enter your sequences, choose output format, and adjust parameters for pairwise or multiple alignment algorithms.
- Precompiled Binaries
- Questionnaire
- Distributions
- Benchmarks
Please help us develop Clustal Omega by filling out a small questionnaire(11 pull-down menus + 1 text box, all optional, can be answered in a minute)
A Clustal Omega package is available for Gentoo Linux. A SlackBuilds package is also available for Slackware. A Debian package is available as part of Debian Med. A wrapperis available for EMBOSS.
We constructed two benchmark data-sets by blending existing structural alignment reference data-sets with homologous unaligned Pfamsequences. 1. HomFam: 94 Homstradsingle domain reference alignments with homologous Pfam sequences (version 25) 2. BaliFam: homologous Pfam sequences (version 26) for BAliBASE 3reference alignments 3. small trees
30 de ago. de 2012 · Multiple alignment of nucleic acid and protein sequences Clustal Omega Latest version of Clustal - fast and scalable (can align hundreds of thousands of sequences in hours), greater accuracy due to new HMM alignment engine
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
The Clustal programs are widely used for carrying out automatic multiple alignment of sets of nucleotide or amino acid sequences. The most familiar version is ClustalW (Thompson et al., 1994), which uses a simple text menu system that is portable to more or less all computer systems.
9 de dez. de 2020 · Clustal Omega is a package for performing fast and accurate multiple sequence alignments (MSAs) of potentially large numbers of protein or DNA/RNA sequences. It is the latest version of the popular and widely used Clustal MSA package [ 2 , 3 ].
