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Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ...
- Cholinesterase inhibitor
Cholinesterase inhibitors (ChEIs), also known as anti-...
- Acetylcholinesterase
Reversible inhibitors occupy the esteratic site for short...
- Cholinesterase inhibitor
A acetilcolinesterase (AChE) é a enzima responsável pela hidrólise do neurotransmissor acetilcolina (ACh) nas sinapses colinérgicas. Nestas sinapses a ACh atua transmitindo a mensagem de um neurônio a outro.
Cholinesterase inhibitor drugs, inhibiting AChE activity, maintain ACh level by decreasing its breakdown rate. Therefore, they boost cholinergic neurotransmission in forebrain regions and compensate for the loss of functioning brain cells.
- Mirjana B Colović, Danijela Z Krstić, Tamara D Lazarević-Pašti, Aleksandra M Bondžić, Vesna M Vasić
- 10.2174/1570159X11311030006
- 2013
- 2013/05
Cholinesterase inhibitors (also called acetylcholinesterase inhibitors) are a group of medicines that block the normal breakdown of acetylcholine. Acetylcholine is the main neurotransmitter found in the body and has functions in both the peripheral nervous system and the central nervous system.
Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds.
