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Há 6 dias · Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited therapeutic...
- Integrating spatial and single-cell transcriptomics reveals ...
Article. Open access. Published: 10 May 2024. Integrating...
- Integrating spatial and single-cell transcriptomics reveals ...
Há 5 horas · Colorectal cancer is the leading cause of cancer death worldwide. The first and second lines of treatment for metastatic colorectal cancer (mCRC) include chemotherapy based on 5-fluorouracil. However, treatment following progression on the first and second line is still unclear. We searched PubMed, Scopus, Cochrane, and Web of Science databases for studies investigating the use of trifluridine ...
20 de mai. de 2024 · The staging evaluation for early-stage rectal cancer includes a pelvic magnetic resonance imaging (MRI) with or without contrast, as well as a computed tomography (CT) of the chest and abdomen to rule out distant metastatic disease.
Há 5 dias · 3555 Background: Wnt/β-catenin signaling is activated by loss-of-function mutations in the adenomatous polyposis coli (APC) gene and plays a key role in tumorigenesis in colorectal cancer (CRC). Tankyrase inhibitors, which cause degradation of β-catenin, are expected to have a promising therapeutic effect for CRC, and the short-form APC mutations predict the sensitivity of CRC cells to ...
9 de mai. de 2024 · Results. This study revealed a malignant tumor cell subpopulation from the single-cell RNA sequencing (scRNA-seq) data. MSI-H CRC was clustered into two subtypes based on the expression profiles of metabolism-related genes, and ENO2 was identified as a hub gene.
24 de mai. de 2024 · Conclusions. This systematic review and meta-analysis of studies examining sign and symptom presentation of EOCRC found that hematochezia, abdominal pain, altered bowel habits, and unexplained weight loss were the most common presenting signs and symptoms in patients diagnosed with EOCRC.
