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  1. pubmed.ncbi.nlm.nih.gov › 39162528A molecular analysis of meropenem-vaborbactam non ... - PubMed

    20 de ago. de 2024 · We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility.

  2. pubmed.ncbi.nlm.nih.gov › 39236156In vivo dendritic cell reprogramming for cancer ... - PubMed

    Há 6 dias · In human tumor spheroids and xenografts, reprogramming to immunogenic dendritic-like cells progressed independently of immunosuppression, which usually limits immunotherapy. Our study paves the way for human clinical trials of in vivo immune cell reprogramming for cancer immunotherapy. Immunotherapy can lead to long-term survival for some ...

  3. www.ncbi.nlm.nih.gov › pmc › articlesKMT2A Rearrangements in Leukemias: Molecular Aspects and ...

    20 de ago. de 2024 · During the juvenile period/adulthood, the incidence of KMT2A rearrangement significantly decreases, and at 50–60 years of age slightly increases again. Overall, it is present in 5–15% of leukemias. Both in children and adults, 50–60% of KMT2A -rearranged cases are ALL, 40% are AML, and <10% are other disease subtypes.

  4. pubmed.ncbi.nlm.nih.gov › 39150724Dietary glycation compounds - implications for human health

    16 de ago. de 2024 · A systematic search in Pubmed (Medline), Scopus and Web of Science using a combination of keywords defining individual glycation compounds and relevant disease patterns linked to the subject area of food, nutrition and diet retrieved 253 original publications relevant to the research question.

  5. www.ncbi.nlm.nih.gov › books › NBK585057Electrophoresis - StatPearls - NCBI Bookshelf

    1 de set. de 2024 · Electrophoresis is the migration of electrically charged molecules under the effect of the electrical field. [1] Tiselius used a liquid medium that had less resolution due to the effect of gravity and diffusion. Electrophoresis utilizes solid support media with buffers to overcome these obstacles.

    • Amit D. Sonagra, Sagar J. Dholariya
    • 2024/06/08

  6. www.nature.com › articles › s41467/024/51694-ySpecific multivalent molecules boost CRISPR-mediated ... - Nature

    22 de ago. de 2024 · Here, by integrating specific multivalent molecules into dCas9-based activators, the authors provide valuable strategies to refine CRISPRa applications and achieve highly efficient gene...

  7. www.nature.com › articles › s41531/024/00776-1A systematic exploration of unexploited genes for oxidative ...

    17 de ago. de 2024 · Abstract. Human disease-associated gene data are accessible through databases, including the Open Targets Platform, DisGeNET, miRTex, RNADisease, and PubChem. However, missing data entries in...