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20 de mai. de 2024 · Encorafenib-cetuximab has been approved for pretreated BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients based on efficacy demonstrated in the randomized phase III BEACON trial.
20 de mai. de 2024 · The metastatic spread is more common for the colonic cancer as for rectal cancer (5.75% vs. 1.7%); these incidences may be in reality significantly higher due to the relatively low rate of detection of the small-nodule disease of the current diagnostic tools.
Há 1 dia · e13735 Background: Rectal cancer (RC) has seen a decreasing incidence and mortality due to national screening guidelines, innovative therapies and new technology. In recent years, however, we have noted shifts in its demographics pertaining to variation in stage at diagnosis and mortality rates amongst various ethnic groups. Minority populations, namely Hispanic (H) and Black (B) patients (pts ...
2 de mai. de 2024 · Peritoneal metastases from colorectal cancer (CRCPM) are related to poor prognosis. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been reported to improve survival, but peritoneal recurrence rates are still high and there is no consensus on the drug of choice for HIPEC.
13 de mai. de 2024 · The primary objective of this study is to develop a prediction model for peritoneal metastasis (PM) in colorectal cancer by integrating the genomic features of primary colorectal cancer, along with clinicopathological features.
9 de mai. de 2024 · In colorectal cancer (CRC), EMT is recognized as a pivotal molecular mechanism contributing to metastasis . Thus, we investigated the expression levels of EMT-associated molecules. Our findings confirmed that the overexpression of ENO2 in CRC cells resulted in decreased expression of E-cadherin and increased expression of N-cadherin ...
11 de mai. de 2024 · Abstract. Patients with colorectal cancer (CRC) often exhibit changes in body composition (BC) which are associated with poorer clinical outcomes. Many studies group colon and rectal cancers...
