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Há 2 dias · Medicinal chemistry research efforts within industry and academia have changed and evolved over the past few years and many new exciting research areas have emerged or been re-energized (e.g., targeted protein degradation, antibody drug conjugates, small molecule RNA targeted therapeutics, biologics, chemical biology/proteomics, new technologies for synthesis and purification of compounds ...
18 de jul. de 2024 · Abstract. The M 4 muscarinic acetylcholine receptor (mAChR) is a biological target for neurocognitive disorders. Compound 1 is an ago -PAM for the M 4 mAChR. Herein, we report the design, synthesis, and evaluation of novel putative M 4 mAChR PAMs based on 1.
12 de jul. de 2024 · Our previous studies identified Bouchardatine derivatives as potential antiobesity agents. However, the 8a-aldehyde moiety rendered them unsuitable for drug development. In this study, we designed two series of novel derivatives to modify this structural feature.
15 de jul. de 2024 · ChemMedChem is a medicinal chemistry journal that connects chemistry, biology & drug discovery, covering small molecules to nanomedicine and biologics.
Há 3 dias · Calculable physicochemical descriptors are a useful guide to assist compound design in medicinal chemistry. It is well established that controlling size, lipophilicity, hydrogen bonding, flexibility and shape, guided by descriptors that approximate to these properties, can greatly increase the chances of suc
Há 5 dias · A synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance. Authors present the in vivo assessment of a compound, F8, from a synthetic antibiotic class ...
5 de jul. de 2024 · Book Editor (s): John Schneekloth, Martin Pettersson, Raimund Mannhold, Helmut Buschmann, Jörg Holenz. , First published: 05 July 2024. https://doi.org/10.1002/9783527840458.index. Book Series: Methods and Principles in Medicinal Chemistry. PDF. Tools.
