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8 de mai. de 2024 · LNCs are a lipid-based nano-drug delivery method that combines the most significant traits of liposomes with polymeric nanoparticles. Structurally, LNCs have an oily core consisting of medium and long triglycerides and an aqueous phase encased in an amphiphilic shell. This manuscript crosstalks LNCs for various biomedical applications.
9 de mai. de 2024 · In principle, this method solves one of the major hurdles in the study of interactions between lipid-based nanometer-sized delivery systems for therapeutic use and blood constituents,...
13 de mai. de 2024 · Abstract. To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid nanoparticle development...
23 de mai. de 2024 · This strategy effectively regulates lipid homeostasis, while demonstrating proven biosafety. Our results present a mRNA therapy for MAFLD and open a new avenue for discovering potent lipids enabling mRNA delivery to specific cells.
10 de mai. de 2024 · Lipid nanoparticles (LNPs) are widely employed for in vivo delivery of mRNA; they protect the mRNA payload from degradation by nucleases and facilitate their delivery to target cells 3. LNPs...
8 de mai. de 2024 · In this paper, we proposed a cationic lipid pair (CLP) strategy, which utilized the liver-targeted ionizable lipid and its derived quaternary ammonium lipid as the CLP to improve liver-to-lung tropism of four-component lipid nanoparticles (LNPs) for in vivo mRNA delivery.
10 de mai. de 2024 · Abstract. Lipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids. However, maintaining the thermostability of mRNA/LNP systems remains challenging.
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