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  1. Há 2 dias · Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge, primarily owing to limited therapeutic options ...

  2. 22 de mai. de 2024 · The frequency of CNS metastasis in colorectal cancer (CRC) is reported to be low, with metastasis to the brain occurring in only 0.6–3.2% of cases [Citation 1]. An increased risk of brain metastasis has been associated with young age, a primary tumor in the rectum, and the presence of lung metastasis [ Citation 1 ].

  3. 10 de mai. de 2024 · Open access. Published: 10 May 2024. Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer. Jing Xiao, Xinyang Yu,...

  4. Há 1 dia · Common sites of metastasis in B: liver 27%, lung 27%, locoregional lymph nodes 9%. In W pts: liver 24%, locoregional lymph nodes 24%, lung 10% and brain 5%. In H pts, 10 of 22(45%) were diagnosed without metastatic disease, though of the 10 who did, 2 had brain involvement. Mortality was highest in B pts at 55%, 33% for W, 20% for A and 18% for ...

  5. 20 de mai. de 2024 · Encorafenib-cetuximab has been approved for pretreated BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients based on efficacy demonstrated in the randomized phase III BEACON trial. The ...

  6. 22 de mai. de 2024 · Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer death worldwide [].In recent years, with the widespread use of cancer screening programs, the introduction of molecularly targeted biological drugs, and the use of surgical and local ablative treatments in metastatic patients, mortality has decreased and survival outcomes have improved [].

  7. 9 de mai. de 2024 · Research. Open access. Published: 09 May 2024. Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high. Junwen Cai, Yuting Yang, Leilei Zhang, Yangyang Fang, Yanjun Zhang, Mingyue Tan, Juan Zhang, Chen Tang, Haitao Ren, Lanni Wang, Guangxin Xiang, Feng Xu, Linhua Lan, Liyi Li &

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