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Há 4 dias · Eduard Batlle. Nature Reviews Gastroenterology & Hepatology ( 2024) Cite this article. Metrics. Abstract. Despite extensive research and improvements in understanding colorectal cancer (CRC),...
Há 3 dias · 3588 Background: The brain-gut axis, a bidirectional network between the central and enteric nervous systems, plays a critical role in modulating the gastrointestinal tract function. Increasing evidence suggests that neuronal signaling molecules can promote gastrointestinal cancers; however, the mechanisms remain unclear. Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter ...
Há 2 dias · TCF7L2 can promote gastric cancer metastasis by regulating PLAUR and forming a MIR100HG/hnRNPA2B1/TCF7L2 axis to promote CRC metastasis . BACH1 is able to activate the transcription of Hexokinase 2 and GAPDH and thereby promotes lung cancer metastasis . These results could suggest new targets for CRC metastasis prevention and prognosis.
10 de mai. de 2024 · Open access. Published: 10 May 2024. Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer. Jing Xiao, Xinyang Yu,...
- Jing Xiao
22 de mai. de 2024 · View PDF View EPUB. This report describes a case of BRAF V600E-mutated colorectal cancer with CNS metastases in which treatment with encorafenib, binimetinib and cetuximab was effective. There is limited information on the ability of encorafenib, binimetinib and cetuximab to enter the CNS.
20 de mai. de 2024 · Encorafenib-cetuximab has been approved for pretreated BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients based on efficacy demonstrated in the randomized phase III BEACON trial. The ...
15 de mai. de 2024 · Colorectal cancer (CRC) is the third most common cancer worldwide, and the second cause of cancer-related death primarily caused by metastatic spread. 1 Approximately 20%–25% of patients present with synchronous metastases, and a significant proportion of stages I–III will develop metachronous metastases (MM). 2 - 7 These are mainly detected dur...
