Resultado da Busca
29 de ago. de 2014 · A better understanding of the role of liver lymphatic metastasis might, in the near future, impact the strategy of systemic therapies after liver resection as for primary colorectal tumors ...
1 de jan. de 2017 · Definition. Colorectal carcinoma comprises all malignant epithelial tumors of the colon and rectum, the most frequent of which is colorectal adenocarcinoma. Unlike in the stomach or small intestine, only tumors that have invaded through the muscularis mucosae into the submucosa are considered malignant in the colon and rectum thus being called ...
9 de dez. de 2021 · Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastases, most frequently to the liver and lung. In the primary tumor, as well as at each metastatic site, the cellular components of the tumor microenvironment (TME) contribute to tumor engraftment and ...
15 de abr. de 2023 · Colorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and management of colorectal liver metastases (CRLMs) remain a challenging clinical issue. Recent genomic evidence has demonstrated the liver tropism of CRC and the presence of a stricter evolutionary bottleneck in the liver as a target organ compared ...
Lymphatic Metastasis. Lymphatic Vessels / anatomy & histology*. Hepatic malignancy with regional lymph node involvement is generally associated with poor prognosis. Lymphatic drainage from the liver to extrahepatic lymph nodes follows a complex and unpredictable pathway. To add to the complexity of management of regional lymph nodes in hepatic ...
To better understand metastatic colorectal cancer, the natural lymphatic drainage from the primary tumor must be examined (see Chapter 1, Fig. 1-8). Colorectal cancer arises from the mucosa and spreads radially toward the serosa. Tumor depth (or T staging) is an important predictor of lymph node involvement.
1 de abr. de 2023 · Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with or without adjuvant chemotherapy, mCRC cannot be eradicated due to a large burden of disseminated cancer cells comprising therapy-resistant metastasis-competent cells.
