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30 de mar. de 2022 · Metastatic colorectal cancer is where cancer has formed in the colon or rectum but spread to other tissues and organs, such as the liver, lungs, or brain. It is a late stage cancer. Colorectal ...
1 de fev. de 2015 · PDF | Metastasis is defined as the spread of cancer cells belonging to primer tumor to different tissue and organs. ... (MMP-9) type IV collagenases in colorectal cancer. Cancer Res 56: 190-196. 77.
1 de ago. de 2012 · Background: Colorectal cancer (CRC) rarely metastasizes to the brain, and the incidence rate has been reported to be 1-2%. Unfortunately, the median survival for patients with brain metastasis (BM) from CRC is short. In this study, we retrospectively investigated the BM from CRC and examined the prognostic factors.
Micro-AbstractBrain metastases have been seen more frequently in the late course of colorectal cancer. In this large cohort, we showed that, despite the advances in systemic therapy, prognosis remains poor for patients who develop brain metastases. Aggressive local therapy should be considered for selected patients.
17 de mar. de 2022 · Summary. The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME. Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal cancer to disentangle factors shaping TME.
26 de nov. de 2012 · Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis ...
Conclusions: Brain metastases from colorectal cancer are infrequently the sole site of metastatic disease, and because survival is dismal regardless of form of therapy chosen, craniotomy is rarely indicated. Exception is the rare patient who has minimum neurologic impairment, a long disease-free interval, a solitary metastasis, and no ...
