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22 de jul. de 2019 · Many colorectal cancers are likely to have spread from the site where they first formed to other parts of the body long before the original tumor can be detected by current screening tests, new study results suggest. Most cancer researchers have assumed that the spread, or metastasis, of tumors typically occurs later in the disease process.
2 de mar. de 2021 · Approximately 50%–60% of patients diagnosed with CRC develop colorectal metastases, 6 –8 and 80%–90% of these patients have unresectable metastatic liver disease. 7,9 –12 Metastatic disease most frequently develops metachronously after treatment of locoregional CRC, with the liver being the most common site of involvement. 13 However, 20%–34% of patients with CRC present with ...
19 de set. de 2019 · Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The most common sites of metastasis are the liver and the peritoneum. Peritoneal carcinomatosis is often considered the end stage of the disease after the tumor has spread to the liver. However, almost half of CRC patients with peritoneal carcinomatosis do not present with liver metastasis. This brings up the ...
14 de mar. de 2024 · Colorectal cancer (CRC) is characterized by its heterogeneity and complex metastatic mechanisms, presenting significant challenges in treatment and prognosis. This study aimed to unravel the intricate interplay between the gut microbiota and metabolic alterations associated with CRC metastasis.
28 de set. de 2022 · A syngeneic MC38 orthotopic mouse model of colorectal cancer metastasis. Joshua D. Greenlee, M. King. Published in Biology Methods and Protocols 28 September 2022. Medicine, Biology. Abstract While subcutaneous tumor models remain the standard for studying drug efficacy in vivo, these tumors rarely metastasize and lack physiological relevance ...
alterations in cancer stem cells. J Exp Clin Cancer Res. 2018;37(1):118. 5. Qin X, et al. An oncogenic phenoscape of colonic stem cell polarization. Cell. 2023;186(25):5554–5568. 6. Caligiuri G, Tuveson DA. Activated fibroblasts in cancer: Perspectives and challenges. Cancer Cell. 2023;41(3):434–449. 7. He K, et al. Metastasis organotropism ...
22 de dez. de 2021 · From the perspective of survival outcomes, the cancer survival of CRC in the whole stage has improved. The 5-year survival rate of metastatic CRC has improved from 4% to 12% over the past 2 or 3 decades, mainly due to the use of intensive chemotherapy [ 2, 3 ]. Peritoneal metastasis (PM) is found in approximately 8% to 15% of patients with CRC ...
